Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells
DNA methylation, repressive histone modifications, and PIWI-interacting RNAs are essential for controlling retroelement silencing in mammalian germ lines. Dysregulation of retroelement silencing is associated with male sterility. Although retroelement silencing mechanisms have been extensively studi...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2022-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/76822 |