Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

Potential role of KRAB-ZFP binding and transcriptional states on DNA methylation of retroelements in human male germ cells

DNA methylation, repressive histone modifications, and PIWI-interacting RNAs are essential for controlling retroelement silencing in mammalian germ lines. Dysregulation of retroelement silencing is associated with male sterility. Although retroelement silencing mechanisms have been extensively studi...

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Bibliographic Details
Main Authors: Kei Fukuda, Yoshinori Makino, Satoru Kaneko, Chikako Shimura, Yuki Okada, Kenji Ichiyanagi, Yoichi Shinkai
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-03-01
Series:eLife
Subjects:
retroelements
DNA methylation
human male germ cells
Online Access:https://elifesciences.org/articles/76822

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