Serum Iron and Haemoglobin Estimation in Oral Submucous Fibrosis and Iron Deficiency Anaemia: A Diagnostic Approach
Introduction: Oral Submucous Fibrosis (OSMF) is a premalignant condition with potential malignant behaviour characterized by juxta-epithelial fibrosis of the oral cavity. In the process of collagen synthesis, iron gets utilized, by the hydroxylation of proline and lysine, leading to decreased se...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-12-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9077/21481_CE[NE]_F(Sh)_PF1(NEAK)_PFA(AK)_PF2(EKAK)_PFA2(AKHN).pdf |
| Summary: | Introduction: Oral Submucous Fibrosis (OSMF) is a premalignant
condition with potential malignant behaviour characterized
by juxta-epithelial fibrosis of the oral cavity. In the process
of collagen synthesis, iron gets utilized, by the hydroxylation
of proline and lysine, leading to decreased serum iron levels.
The trace element like iron is receiving much attention in the
detection of oral cancer and precancerous condition like OSMF
as it was found to be significantly altered in these conditions.
Aim: The aim of this study was to compare the haemoglobin and
serum iron values of OSMF subjects with that of iron deficiency
anaemia subjects.
Materials and Methods: Total of 120 subjects were included,
40 subjects with the OSMF, 40 with the iron deficiency anemia
without tobacco chewing habit, 40 healthy control subjects
without OSMF and iron deficiency anaemia. A total of 5ml of
venous blood was withdrawn from all the subjects and serum
iron and haemoglobin levels were estimated for all the subjects.
Estimation of iron was done using Ferrozine method and
haemoglobin by Sahli’s method. The statistical method applied
were Kruskal Wallis, Mann Whitney and Pearson correlation
coefficient test.
Results: There was a statistically significant difference in serum
iron and haemoglobin level in all three groups (p<0.05). The
serum iron level was lowest in OSMF group and haemoglobin
was lowest in iron deficiency anaemia group. A progressive
decrease in serum iron and haemoglobin levels from Stage
I of OSMF to the Stage IV of OSMF was also observed. The
iron deficiency anaemia group was not found to be suffering
from OSMF in the absence of areca-nut or tobacco chewing
habits, but OSMF patients with chewing habits were found to
be suffering from iron deficiency anaemia.
Conclusion: There is a progressive decrease in serum iron and
haemoglobin levels from Stage I of OSMF to the Stage IV of
OSMF so it can be used as an auxillary test in assessment of
prognosis of the disease. |
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| ISSN: | 2249-782X 0973-709X |