Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease
Background. Nonalcoholic fatty pancreas disease sis an excessive fat infiltration of the pancreas due to obesity in the absence of secondary steatosis. Nonalcoholic fatty liver disease is associated with progredient course; the question of whether the presence and progression of nonalcoholic fatty p...
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Zaslavsky O.Yu.
2017-09-01
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| Series: | Zdorovʹe Rebenka |
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| Online Access: | http://childshealth.zaslavsky.com.ua/article/view/112835 |
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| author | Yu.M. Stepanov O.Yu. Lukianenko N.Yu. Zavhorodnia N.H. Hravyrovska |
| author_facet | Yu.M. Stepanov O.Yu. Lukianenko N.Yu. Zavhorodnia N.H. Hravyrovska |
| author_sort | Yu.M. Stepanov |
| collection | DOAJ |
| description | Background. Nonalcoholic fatty pancreas disease sis an excessive fat infiltration of the pancreas due to obesity in the absence of secondary steatosis. Nonalcoholic fatty liver disease is associated with progredient course; the question of whether the presence and progression of nonalcoholic fatty pancreas disease are accompanied by specific structural and laboratory findings is still remain unclear. The purpose of our study was to establish the features of sonological and laboratory findings in children with nonalcoholic fatty pancreas disease depending on steatosis degree. Materials and methods. We observed 93 children aged 7 to 17 years, the average age was 11.87 ± 2.82 years. Degree of pancreatic steatosis was evaluated by ultrasonography. In order to determine pancreatic fibrosis and steatosis, shear wave elastography and steatometry (quantitative estimation of the ultrasound attenuation with determination of average ultrasound attenuation coefficient (UAC)) were performed using Ultima PA Expert apparatus (Radmir, Ukraine). Liver fibrosis and steatosis were diagnosed by means of Fibroscan 502 Touch (France) with controlled attenuation parameter (CAP) function. According to the presence of pancreatic steatosis, children were divided into the following groups: group 1 — 50 children with pancreatic steatosis and obesity/overweight; this group was divided into subgroups: S1 subgroup — 20 children with degree 1 pancreatic steatosis, S2 subgroup — 22 patients with d egree 2 pancreatic steatosis, S3 — 8 children with degree 3 pancreatic steatosis; group 2 — 30 persons without pancreatic steatosis with obesity/overweight, group 3 — 13 children with normal weight. All patients and their parents agreed to participate in the study. We provided blood count with determination of erythrocyte sedimentation rate (ESR), liver function test (alanin aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGTP)) and test for serum amylase level. Insulin level was determined by immunoassay with calculation of HOMA-IR. Statistical analysis was performed using Statistica 7.0 software by one-way analysis of variance (ANOVA) followed by post hoc analysis. Results. Children with degree 3 pancreatic steatosis as compared to group 3 demonstrated higher level of ESR — by 1.86 times (p = 0.01), ALT — by 1.86 times (p = 0.006), AST — by 1.96 times (p = 0.00019), GGTP — by 2.10 times (p = 0.0001). We found that patients with pancreatic steatosis had higher level of insulin as compared to the control group (S1 subgroup — 18.38 ± 5.07 μU/ml; S2 subgroup — 30.76 ± 3.92 μU/ml; S3 subgroup — 33.70 ± 5.37 μU/ml; group 2 — 18.70 ± 2.98 μU/ml; group 3 — 9.480 ± 5.067 μU/ml (p = 0.00262)). Also, patients with pancreatic steatosis demonstrated higher level of HOMA index as compared to the control group (S1 — 4.04 ± 0.87; S2 — 7.11 ± 0.96; S3 — 7.99 ± 1.35; group 2 — 3.81 ± 0.73; group 3 — 1.94 ± 0.92 (p = 0.00156)). CAP level increased in patients with pancreatic steatosis (S1 subgroup — 234.50 ± 9.94 dB/m; S2 — 239.05 ± 8.99 dB/m; S3 — 245.33 ± 17.21 dB/m; group 2 — 197.87 ± 7.70 dB/m; group 3 — 172.754 ± 12.170 dB/m (p = 0.00156)). UAC reached maximal level in children of S3 subgroup (S1 — 2.55 ± 0.08 dB/cm; S2 — 2.56 ± 0.09 dB/cm; S3 — 2.74 ± 0.14 dB/cm; group 2 — 2.26 ± 0.08 dB/cm; group 3 — 1.72 ± 0.15 dB/cm (p = 0.00001)). Patients with pancreatic steatosis had higher level of liver and pancreatic stiffness, but significance of difference was low (p = 0.59). Conclusions. Pediatric nonalcoholic fatty pancreas disease was accompanied by liver steatosis, higher level of inflammation markers and insulin resistance that increased with growth of steatosis degree. |
| first_indexed | 2024-12-24T04:24:38Z |
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| language | English |
| last_indexed | 2024-12-24T04:24:38Z |
| publishDate | 2017-09-01 |
| publisher | Zaslavsky O.Yu. |
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| spelling | doaj.art-ede5f8a9113846b3b574e63e4678cfbb2022-12-21T17:15:40ZengZaslavsky O.Yu.Zdorovʹe Rebenka2224-05512307-11682017-09-0112667067610.22141/2224-0551.12.6.2017.112835112835Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas diseaseYu.M. Stepanov0O.Yu. Lukianenko1N.Yu. Zavhorodnia2N.H. Hravyrovska3State Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineState Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineState Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineState Institution “Institute of Gastroenterology of the National Academy of Medical Sciences of Ukraine”, Dnipro, UkraineBackground. Nonalcoholic fatty pancreas disease sis an excessive fat infiltration of the pancreas due to obesity in the absence of secondary steatosis. Nonalcoholic fatty liver disease is associated with progredient course; the question of whether the presence and progression of nonalcoholic fatty pancreas disease are accompanied by specific structural and laboratory findings is still remain unclear. The purpose of our study was to establish the features of sonological and laboratory findings in children with nonalcoholic fatty pancreas disease depending on steatosis degree. Materials and methods. We observed 93 children aged 7 to 17 years, the average age was 11.87 ± 2.82 years. Degree of pancreatic steatosis was evaluated by ultrasonography. In order to determine pancreatic fibrosis and steatosis, shear wave elastography and steatometry (quantitative estimation of the ultrasound attenuation with determination of average ultrasound attenuation coefficient (UAC)) were performed using Ultima PA Expert apparatus (Radmir, Ukraine). Liver fibrosis and steatosis were diagnosed by means of Fibroscan 502 Touch (France) with controlled attenuation parameter (CAP) function. According to the presence of pancreatic steatosis, children were divided into the following groups: group 1 — 50 children with pancreatic steatosis and obesity/overweight; this group was divided into subgroups: S1 subgroup — 20 children with degree 1 pancreatic steatosis, S2 subgroup — 22 patients with d egree 2 pancreatic steatosis, S3 — 8 children with degree 3 pancreatic steatosis; group 2 — 30 persons without pancreatic steatosis with obesity/overweight, group 3 — 13 children with normal weight. All patients and their parents agreed to participate in the study. We provided blood count with determination of erythrocyte sedimentation rate (ESR), liver function test (alanin aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGTP)) and test for serum amylase level. Insulin level was determined by immunoassay with calculation of HOMA-IR. Statistical analysis was performed using Statistica 7.0 software by one-way analysis of variance (ANOVA) followed by post hoc analysis. Results. Children with degree 3 pancreatic steatosis as compared to group 3 demonstrated higher level of ESR — by 1.86 times (p = 0.01), ALT — by 1.86 times (p = 0.006), AST — by 1.96 times (p = 0.00019), GGTP — by 2.10 times (p = 0.0001). We found that patients with pancreatic steatosis had higher level of insulin as compared to the control group (S1 subgroup — 18.38 ± 5.07 μU/ml; S2 subgroup — 30.76 ± 3.92 μU/ml; S3 subgroup — 33.70 ± 5.37 μU/ml; group 2 — 18.70 ± 2.98 μU/ml; group 3 — 9.480 ± 5.067 μU/ml (p = 0.00262)). Also, patients with pancreatic steatosis demonstrated higher level of HOMA index as compared to the control group (S1 — 4.04 ± 0.87; S2 — 7.11 ± 0.96; S3 — 7.99 ± 1.35; group 2 — 3.81 ± 0.73; group 3 — 1.94 ± 0.92 (p = 0.00156)). CAP level increased in patients with pancreatic steatosis (S1 subgroup — 234.50 ± 9.94 dB/m; S2 — 239.05 ± 8.99 dB/m; S3 — 245.33 ± 17.21 dB/m; group 2 — 197.87 ± 7.70 dB/m; group 3 — 172.754 ± 12.170 dB/m (p = 0.00156)). UAC reached maximal level in children of S3 subgroup (S1 — 2.55 ± 0.08 dB/cm; S2 — 2.56 ± 0.09 dB/cm; S3 — 2.74 ± 0.14 dB/cm; group 2 — 2.26 ± 0.08 dB/cm; group 3 — 1.72 ± 0.15 dB/cm (p = 0.00001)). Patients with pancreatic steatosis had higher level of liver and pancreatic stiffness, but significance of difference was low (p = 0.59). Conclusions. Pediatric nonalcoholic fatty pancreas disease was accompanied by liver steatosis, higher level of inflammation markers and insulin resistance that increased with growth of steatosis degree.http://childshealth.zaslavsky.com.ua/article/view/112835nonalcoholic fatty pancreas diseasenonalcoholic fatty liver diseasesteatometryelastometrychildren |
| spellingShingle | Yu.M. Stepanov O.Yu. Lukianenko N.Yu. Zavhorodnia N.H. Hravyrovska Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease Zdorovʹe Rebenka nonalcoholic fatty pancreas disease nonalcoholic fatty liver disease steatometry elastometry children |
| title | Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| title_full | Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| title_fullStr | Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| title_full_unstemmed | Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| title_short | Influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| title_sort | influence of pancreatic steatosis severity on the course of pediatric nonalcoholic fatty pancreas disease |
| topic | nonalcoholic fatty pancreas disease nonalcoholic fatty liver disease steatometry elastometry children |
| url | http://childshealth.zaslavsky.com.ua/article/view/112835 |
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