P3H4 is correlated with clinicopathological features and prognosis in bladder cancer
Abstract Background Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1507-2 |
| _version_ | 1819106598228852736 |
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| author | Wangjian Li Lihong Ye Yongliang Chen Peng Chen |
| author_facet | Wangjian Li Lihong Ye Yongliang Chen Peng Chen |
| author_sort | Wangjian Li |
| collection | DOAJ |
| description | Abstract Background Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved in several types of human cancer. However, the effect of P3H4 in bladder cancer remains unknown. Methods The mRNA expression of P3H4 was measured in 44 paired tumors and adjacent normal tissues by using real-time reverse transcription-polymerase chain reaction. RNA-Seq data of 389 patients with bladder cancer were downloaded to investigate the effect of P3H4 on bladder cancer from The Cancer Genome Atlas (TCGA) project. Results P3H4 was overexpressed in bladder cancer compared with the adjacent normal tissue both in our tissue samples and TCGA samples. The mRNA expression of P3H4 was significantly related to several clinicopathological factors of bladder cancer, including age, race category, histologic grade, tumor histologic subtype, and AJCC stage. The high P3H4 expression group had a shorter overall survival (OS) than the low P3H4 expression group. Univariate Cox regression analysis showed that age, angiolymphatic invasion, lymph node metastasis, tumor histologic subtype, metastasis, AJCC stage, and P3H4 were significantly related to OS. Moreover, multivariate Cox analysis revealed that P3H4, as well as age and AJCC stage, was an independent predictor of poor OS. Conclusion Given its tumorigenic role, P3H4 may serve as a promising tumor-promoting gene in bladder cancer. |
| first_indexed | 2024-12-22T02:40:41Z |
| format | Article |
| id | doaj.art-ede66e4863bb4f54bf9d553ee93fb871 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-22T02:40:41Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-ede66e4863bb4f54bf9d553ee93fb8712022-12-21T18:41:39ZengBMCWorld Journal of Surgical Oncology1477-78192018-10-011611610.1186/s12957-018-1507-2P3H4 is correlated with clinicopathological features and prognosis in bladder cancerWangjian Li0Lihong Ye1Yongliang Chen2Peng Chen3Department of Urology, Shaoxing Hospital of China Medical UniversityDepartment of Urology, Shaoxing Hospital of China Medical UniversityDepartment of Urology, Shaoxing Hospital of China Medical UniversityDepartment of Radiation Oncology, Hangzhou Cancer HospitalAbstract Background Genetic alterations play a significant role in the progression of bladder cancer. Identifying novel biomarkers to personalize the therapeutic regimen and evaluate the prognosis of patients with bladder cancer is vital. Prolyl 3-hydroxylase family member 4 (P3H4) is significantly involved in several types of human cancer. However, the effect of P3H4 in bladder cancer remains unknown. Methods The mRNA expression of P3H4 was measured in 44 paired tumors and adjacent normal tissues by using real-time reverse transcription-polymerase chain reaction. RNA-Seq data of 389 patients with bladder cancer were downloaded to investigate the effect of P3H4 on bladder cancer from The Cancer Genome Atlas (TCGA) project. Results P3H4 was overexpressed in bladder cancer compared with the adjacent normal tissue both in our tissue samples and TCGA samples. The mRNA expression of P3H4 was significantly related to several clinicopathological factors of bladder cancer, including age, race category, histologic grade, tumor histologic subtype, and AJCC stage. The high P3H4 expression group had a shorter overall survival (OS) than the low P3H4 expression group. Univariate Cox regression analysis showed that age, angiolymphatic invasion, lymph node metastasis, tumor histologic subtype, metastasis, AJCC stage, and P3H4 were significantly related to OS. Moreover, multivariate Cox analysis revealed that P3H4, as well as age and AJCC stage, was an independent predictor of poor OS. Conclusion Given its tumorigenic role, P3H4 may serve as a promising tumor-promoting gene in bladder cancer.http://link.springer.com/article/10.1186/s12957-018-1507-2Bladder cancerP3H4Clinicopathological featuresPrognosis |
| spellingShingle | Wangjian Li Lihong Ye Yongliang Chen Peng Chen P3H4 is correlated with clinicopathological features and prognosis in bladder cancer World Journal of Surgical Oncology Bladder cancer P3H4 Clinicopathological features Prognosis |
| title | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
| title_full | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
| title_fullStr | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
| title_full_unstemmed | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
| title_short | P3H4 is correlated with clinicopathological features and prognosis in bladder cancer |
| title_sort | p3h4 is correlated with clinicopathological features and prognosis in bladder cancer |
| topic | Bladder cancer P3H4 Clinicopathological features Prognosis |
| url | http://link.springer.com/article/10.1186/s12957-018-1507-2 |
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