Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics
One strategy for bringing aptamers more into the mainstream of biomedical diagnostics and therapeutics is to exploit niche applications where aptamers are truly needed or wanted for their innate differences versus antibodies. This brief review article highlights some of those relatively rare applica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/6/693 |
| _version_ | 1797483436442648576 |
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| author | John G. Bruno |
| author_facet | John G. Bruno |
| author_sort | John G. Bruno |
| collection | DOAJ |
| description | One strategy for bringing aptamers more into the mainstream of biomedical diagnostics and therapeutics is to exploit niche applications where aptamers are truly needed or wanted for their innate differences versus antibodies. This brief review article highlights some of those relatively rare applications in which aptamers are necessary or better suited to the user requirements than antibodies with explanations for why the aptamer is a necessary or superior choice. These situations include when no commercial antibody exists, when antibodies are excessively difficult to develop against a particular target because the target is highly toxic to host animals, when antibodies fail to discriminate closely related targets, when a smaller size is preferable to penetrate a tissue, when humanized monoclonal antibodies are too expensive and when the target is rapidly evolving or mutating. Examples of each are provided to illustrate these points. |
| first_indexed | 2024-03-09T22:47:55Z |
| format | Article |
| id | doaj.art-ede722bb1a08488fb881a44d7d62727e |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:47:55Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ede722bb1a08488fb881a44d7d62727e2023-11-23T18:27:07ZengMDPI AGPharmaceuticals1424-82472022-06-0115669310.3390/ph15060693Applications in Which Aptamers Are Needed or Wanted in Diagnostics and TherapeuticsJohn G. Bruno0Nanohmics Inc., 6201 E. Oltorf Street, Suite 400, Austin, TX 78640, USAOne strategy for bringing aptamers more into the mainstream of biomedical diagnostics and therapeutics is to exploit niche applications where aptamers are truly needed or wanted for their innate differences versus antibodies. This brief review article highlights some of those relatively rare applications in which aptamers are necessary or better suited to the user requirements than antibodies with explanations for why the aptamer is a necessary or superior choice. These situations include when no commercial antibody exists, when antibodies are excessively difficult to develop against a particular target because the target is highly toxic to host animals, when antibodies fail to discriminate closely related targets, when a smaller size is preferable to penetrate a tissue, when humanized monoclonal antibodies are too expensive and when the target is rapidly evolving or mutating. Examples of each are provided to illustrate these points.https://www.mdpi.com/1424-8247/15/6/693aptamer<i>Cyclospora</i>diagnosticliver flukehumanizedmonoclonal antibody |
| spellingShingle | John G. Bruno Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics Pharmaceuticals aptamer <i>Cyclospora</i> diagnostic liver fluke humanized monoclonal antibody |
| title | Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics |
| title_full | Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics |
| title_fullStr | Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics |
| title_full_unstemmed | Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics |
| title_short | Applications in Which Aptamers Are Needed or Wanted in Diagnostics and Therapeutics |
| title_sort | applications in which aptamers are needed or wanted in diagnostics and therapeutics |
| topic | aptamer <i>Cyclospora</i> diagnostic liver fluke humanized monoclonal antibody |
| url | https://www.mdpi.com/1424-8247/15/6/693 |
| work_keys_str_mv | AT johngbruno applicationsinwhichaptamersareneededorwantedindiagnosticsandtherapeutics |