Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a stro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2017-05-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdf |
| _version_ | 1818567418610450432 |
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| author | Kelvin H. M. Kwok Karen S. L. Lam |
| author_facet | Kelvin H. M. Kwok Karen S. L. Lam |
| author_sort | Kelvin H. M. Kwok |
| collection | DOAJ |
| description | Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis. Animal studies have demonstrated a beneficial role of FGF21 in protecting against aberrant lipid profile, while recent development in FGF21 mimetics has provided further insight into the lipid-lowering effects of FGF21 signaling. The present review summarizes the physiological roles of FGF21, and discusses major breakthroughs and limitations of FGF21 mimetic-based therapeutic strategies for treating atherosclerosis. |
| first_indexed | 2024-12-14T06:23:09Z |
| format | Article |
| id | doaj.art-ede7eeed0ac74c329dcacb6e1120c866 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-12-14T06:23:09Z |
| publishDate | 2017-05-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-ede7eeed0ac74c329dcacb6e1120c8662022-12-21T23:13:45ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782017-05-0132214515110.3803/EnM.2017.32.2.145Fibroblast Growth Factor 21 Mimetics for Treating AtherosclerosisKelvin H. M. Kwok0Karen S. L. Lam1State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong.State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong.Fibroblast growth factor 21 (FGF21) is an atypical member of the FGF family. Acting in an endocrine fashion, it increases glucose uptake, modulates lipid metabolism, and sensitizes insulin response in metabolically active organs, including the liver and adipose tissue. Emerging evidence shows a strong correlation between circulating FGF21 levels and the incidence and severity of atherosclerosis. Animal studies have demonstrated a beneficial role of FGF21 in protecting against aberrant lipid profile, while recent development in FGF21 mimetics has provided further insight into the lipid-lowering effects of FGF21 signaling. The present review summarizes the physiological roles of FGF21, and discusses major breakthroughs and limitations of FGF21 mimetic-based therapeutic strategies for treating atherosclerosis.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdfFibroblast growth factor 21AtherosclerosisDyslipidemia |
| spellingShingle | Kelvin H. M. Kwok Karen S. L. Lam Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis Endocrinology and Metabolism Fibroblast growth factor 21 Atherosclerosis Dyslipidemia |
| title | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis |
| title_full | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis |
| title_fullStr | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis |
| title_full_unstemmed | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis |
| title_short | Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis |
| title_sort | fibroblast growth factor 21 mimetics for treating atherosclerosis |
| topic | Fibroblast growth factor 21 Atherosclerosis Dyslipidemia |
| url | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-145.pdf |
| work_keys_str_mv | AT kelvinhmkwok fibroblastgrowthfactor21mimeticsfortreatingatherosclerosis AT karensllam fibroblastgrowthfactor21mimeticsfortreatingatherosclerosis |