Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects
Background and Aims: Recognition of heart failure with preserved ejection fraction (HFpEF) at an early stage in mass screening is desirable, but difficult to achieve. We examined whether the fibrosis (Fib)-4 index, a simple index of liver stiffness/fibrosis, could be used as a screening tool to sele...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572322001571 |
| _version_ | 1828004351755419648 |
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| author | Chisato Okamoto Osamu Tsukamoto Takuya Hasegawa Tatsuro Hitsumoto Ken Matsuoka Makoto Amaki Hideaki Kanzaki Chisato Izumi Seiji Takashima Shin Ito Masafumi Kitakaze |
| author_facet | Chisato Okamoto Osamu Tsukamoto Takuya Hasegawa Tatsuro Hitsumoto Ken Matsuoka Makoto Amaki Hideaki Kanzaki Chisato Izumi Seiji Takashima Shin Ito Masafumi Kitakaze |
| author_sort | Chisato Okamoto |
| collection | DOAJ |
| description | Background and Aims: Recognition of heart failure with preserved ejection fraction (HFpEF) at an early stage in mass screening is desirable, but difficult to achieve. We examined whether the fibrosis (Fib)-4 index, a simple index of liver stiffness/fibrosis, could be used as a screening tool to select candidates requiring expert diagnostics. Methods: Individuals who participated in annual health checks between 2006 and 2007 in Arita-cho, Saga, Japan, with no history of cardiovascular disease and EF ≥ 50% were enrolled (total 710; 258 men; median age, 59 years). Results: Participants were divided into 5 groups according to HFpEF risk: 215 (30%), 100 (14%), 171 (24%), 163 (23%), and 61 (9%) with Heart Failure Association (HFA)-PEFF scores of 0, 1, 2, 3, and 4–6 points, respectively. The highest HFpEF risk group (HFA-PEFF score, 4–6 points) showed poor prognosis for the clinical events of all-cause mortality and hospitalization for HF (log-rank test, P = .002). The Fib-4 index was correlated with HFpEF risk stratification (rs = 0.526), and increment in the Fib-4 index was independently linked to high HFpEF risk by multiple logistic regression analysis (adjusted odds ratio, 1.311; 95% confidence interval, 1.078–1.595; P = .007). The Fib-4 index stratified clinical prognosis (log-rank test, P < .001) was an independent predictor of all-cause mortality and hospitalization for HF (hazard ratio, 1.305; 95% confidence interval, 1.139–1.495; P < .001). Conclusion: The Fib-4 index can be used to select appropriate candidates for a detailed examination of HFpEF in a subclinical population. |
| first_indexed | 2024-04-10T07:13:29Z |
| format | Article |
| id | doaj.art-ede9266be4ef4e18b0993d8a7186731f |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-04-10T07:13:29Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-ede9266be4ef4e18b0993d8a7186731f2023-02-26T04:28:39ZengElsevierGastro Hep Advances2772-57232023-01-0122170181Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical SubjectsChisato Okamoto0Osamu Tsukamoto1Takuya Hasegawa2Tatsuro Hitsumoto3Ken Matsuoka4Makoto Amaki5Hideaki Kanzaki6Chisato Izumi7Seiji Takashima8Shin Ito9Masafumi Kitakaze10Department of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, Japan; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, Japan; Correspondence: Address correspondence to: Osamu Tsukamoto, MD, PhD, Department of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, 2-2, Yamadaoka, Suita, Osaka 565-0871, Japan.Department of Cardiovascular Medicine, Garatia Hospital, Mino, Osaka, JapanDepartment of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, JapanDepartment of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, JapanDepartment of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, JapanDepartment of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, JapanDepartment of Medical Biochemistry, Osaka University Graduate School of Medicine/Frontier Biosciences, Suita, Osaka, Japan; Department of Clinical Medicine and Development, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan; Department of Cardiovascular Medicine, Hanwa Memorial Hospital, Osaka, Osaka, Japan; Masafumi Kitakaze, MD, PhD, Hanwa Memorial Hospital, 3-5-8 Minamisumiyoshi Sumiyoshi, Osaka, Osaka 558-0041, Japan.Background and Aims: Recognition of heart failure with preserved ejection fraction (HFpEF) at an early stage in mass screening is desirable, but difficult to achieve. We examined whether the fibrosis (Fib)-4 index, a simple index of liver stiffness/fibrosis, could be used as a screening tool to select candidates requiring expert diagnostics. Methods: Individuals who participated in annual health checks between 2006 and 2007 in Arita-cho, Saga, Japan, with no history of cardiovascular disease and EF ≥ 50% were enrolled (total 710; 258 men; median age, 59 years). Results: Participants were divided into 5 groups according to HFpEF risk: 215 (30%), 100 (14%), 171 (24%), 163 (23%), and 61 (9%) with Heart Failure Association (HFA)-PEFF scores of 0, 1, 2, 3, and 4–6 points, respectively. The highest HFpEF risk group (HFA-PEFF score, 4–6 points) showed poor prognosis for the clinical events of all-cause mortality and hospitalization for HF (log-rank test, P = .002). The Fib-4 index was correlated with HFpEF risk stratification (rs = 0.526), and increment in the Fib-4 index was independently linked to high HFpEF risk by multiple logistic regression analysis (adjusted odds ratio, 1.311; 95% confidence interval, 1.078–1.595; P = .007). The Fib-4 index stratified clinical prognosis (log-rank test, P < .001) was an independent predictor of all-cause mortality and hospitalization for HF (hazard ratio, 1.305; 95% confidence interval, 1.139–1.495; P < .001). Conclusion: The Fib-4 index can be used to select appropriate candidates for a detailed examination of HFpEF in a subclinical population.http://www.sciencedirect.com/science/article/pii/S2772572322001571Heart-liver axisLiver stiffnessHFpEFMass screening |
| spellingShingle | Chisato Okamoto Osamu Tsukamoto Takuya Hasegawa Tatsuro Hitsumoto Ken Matsuoka Makoto Amaki Hideaki Kanzaki Chisato Izumi Seiji Takashima Shin Ito Masafumi Kitakaze Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects Gastro Hep Advances Heart-liver axis Liver stiffness HFpEF Mass screening |
| title | Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects |
| title_full | Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects |
| title_fullStr | Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects |
| title_full_unstemmed | Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects |
| title_short | Candidate Screening for Heart Failure With Preserved Ejection Fraction Clinic by Fib-4 Index From Subclinical Subjects |
| title_sort | candidate screening for heart failure with preserved ejection fraction clinic by fib 4 index from subclinical subjects |
| topic | Heart-liver axis Liver stiffness HFpEF Mass screening |
| url | http://www.sciencedirect.com/science/article/pii/S2772572322001571 |
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