Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes
Abstract Endogenous virus elements (EVEs) are viral-derived sequences integrated into their host genomes. EVEs of the Jingchuvirales order were detected in a wide range of insect genomes covering several distantly related families. Moreover, Jingchuvirales-derived glycoproteins were recently associa...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2023-04-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000100801&tlng=en |
| _version_ | 1797849009502552064 |
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| author | Filipe Zimmer Dezordi Gutembergmann Batista Coutinho Yago José Mariz Dias Gabriel Luz Wallau |
| author_facet | Filipe Zimmer Dezordi Gutembergmann Batista Coutinho Yago José Mariz Dias Gabriel Luz Wallau |
| author_sort | Filipe Zimmer Dezordi |
| collection | DOAJ |
| description | Abstract Endogenous virus elements (EVEs) are viral-derived sequences integrated into their host genomes. EVEs of the Jingchuvirales order were detected in a wide range of insect genomes covering several distantly related families. Moreover, Jingchuvirales-derived glycoproteins were recently associated by our group with the origin of a putative new retrovirus based on a glycoprotein captured by a mosquito retrotransposon. But, except for mosquitoes, there is a lack of a more detailed understanding of the endogenization mechanism, timing, and frequency per Jingchuvirales viral lineages. Here we screened Jingchuvirales glycoprotein-derived EVEs (Jg-EVEs) in eukaryotic genomes. We found six distinct endogenization events of Jg-EVEs, that belong to two out of five known Jingchuvirales families (Chuviridae and Natareviridae). For seven arthropod families bearing Jg-EVEs there is no register of bona fide circulating chuvirus infection. Hence, our results show that Jingchuvirales viruses infected or still infect these host families. Although we found abundant evidence of LTR-Gypsy retrotransposons fragments associated with the glycoprotein in Hymenoptera and other insect orders, our results show that the widespread distribution of Jingchuvirales glycoproteins in extant Arhtropods is a result of multiple ancient endogenization events and that these virus fossils are being vertically inherited in Arthropods genomes for millions of years. |
| first_indexed | 2024-04-09T18:38:00Z |
| format | Article |
| id | doaj.art-ede97d17631747779e3120498a411d1a |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-09T18:38:00Z |
| publishDate | 2023-04-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-ede97d17631747779e3120498a411d1a2023-04-11T07:32:07ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852023-04-0146110.1590/1678-4685-gmb-2022-0218Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomesFilipe Zimmer DezordiGutembergmann Batista CoutinhoYago José Mariz DiasGabriel Luz Wallauhttps://orcid.org/0000-0002-1419-5713Abstract Endogenous virus elements (EVEs) are viral-derived sequences integrated into their host genomes. EVEs of the Jingchuvirales order were detected in a wide range of insect genomes covering several distantly related families. Moreover, Jingchuvirales-derived glycoproteins were recently associated by our group with the origin of a putative new retrovirus based on a glycoprotein captured by a mosquito retrotransposon. But, except for mosquitoes, there is a lack of a more detailed understanding of the endogenization mechanism, timing, and frequency per Jingchuvirales viral lineages. Here we screened Jingchuvirales glycoprotein-derived EVEs (Jg-EVEs) in eukaryotic genomes. We found six distinct endogenization events of Jg-EVEs, that belong to two out of five known Jingchuvirales families (Chuviridae and Natareviridae). For seven arthropod families bearing Jg-EVEs there is no register of bona fide circulating chuvirus infection. Hence, our results show that Jingchuvirales viruses infected or still infect these host families. Although we found abundant evidence of LTR-Gypsy retrotransposons fragments associated with the glycoprotein in Hymenoptera and other insect orders, our results show that the widespread distribution of Jingchuvirales glycoproteins in extant Arhtropods is a result of multiple ancient endogenization events and that these virus fossils are being vertically inherited in Arthropods genomes for millions of years.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000100801&tlng=enJingchuviralesendogenous virusesgenomeinsects |
| spellingShingle | Filipe Zimmer Dezordi Gutembergmann Batista Coutinho Yago José Mariz Dias Gabriel Luz Wallau Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes Genetics and Molecular Biology Jingchuvirales endogenous viruses genome insects |
| title | Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes |
| title_full | Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes |
| title_fullStr | Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes |
| title_full_unstemmed | Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes |
| title_short | Ancient origin of Jingchuvirales derived glycoproteins integrated in arthropod genomes |
| title_sort | ancient origin of jingchuvirales derived glycoproteins integrated in arthropod genomes |
| topic | Jingchuvirales endogenous viruses genome insects |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000100801&tlng=en |
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