Fungal Mushrooms: A Natural Compound With Therapeutic Applications
Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.925387/full |
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| author | Rishi Man Chugh Pooja Mittal Namratha MP Tanu Arora Tanima Bhattacharya Tanima Bhattacharya Hitesh Chopra Simona Cavalu Rupesh K. Gautam |
| author_facet | Rishi Man Chugh Pooja Mittal Namratha MP Tanu Arora Tanima Bhattacharya Tanima Bhattacharya Hitesh Chopra Simona Cavalu Rupesh K. Gautam |
| author_sort | Rishi Man Chugh |
| collection | DOAJ |
| description | Fungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century. |
| first_indexed | 2024-04-13T04:41:58Z |
| format | Article |
| id | doaj.art-edea4d372eb646798d97b4b7773eb6b4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T04:41:58Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-edea4d372eb646798d97b4b7773eb6b42022-12-22T03:01:58ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-07-011310.3389/fphar.2022.925387925387Fungal Mushrooms: A Natural Compound With Therapeutic ApplicationsRishi Man Chugh0Pooja Mittal1Namratha MP2Tanu Arora3Tanima Bhattacharya4Tanima Bhattacharya5Hitesh Chopra6Simona Cavalu7Rupesh K. Gautam8Department of Radiation Oncology, University of Kansas Medical Center, Kansas, KS, United StatesSchool of Pharmaceutical Sciences, RIMT University, Mandi Gobindgarh, Punjab, IndiaCHRIST (Deemed to be University), Bangalore, IndiaDepartment of Radiation Oncology, University of Kansas Medical Center, Kansas, KS, United StatesInnovation, Incubation and Industry (i-cube) Laboratory, Techno India NJR Institute of Technology, Udaipur, IndiaCollege of Chemistry and Chemical Engineering, Hubei University, Hubei, ChinaChitkara College of Pharmacy, Chitkara University, Rajpura, IndiaFaculty of Medicine and Pharmacy, University of Oradea, Oradea, RomaniaMM School of Pharmacy, MM University, Sadopur-Ambala, IndiaFungi are extremely diverse in terms of morphology, ecology, metabolism, and phylogeny. Approximately, 130 medicinal activities like antitumor, immunomodulation, antioxidant, radical scavenging, cardioprotective and antiviral actions are assumed to be produced by the various varieties of medicinal mushrooms. The polysaccharides, present in mushrooms like β-glucans, micronutrients, antioxidants like glycoproteins, triterpenoids, flavonoids, and ergosterols can help establish natural resistance against infections and toxins.. Clinical trials have been performed on mushrooms like Agaricus blazei Murrill Kyowa for their anticancer effect, A. blazei Murrill for its antihypertensive and cardioprotective effects, and some other mushrooms had also been evaluated for their neurological effects. The human evaluation dose studies had been also performed and the toxicity dose was evaluated from the literature for number of mushrooms. All the mushrooms were found to be safe at a dose of 2000 mg/kg but some with mild side effects. The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems. In complement to the vital nutritional significance of medicinal mushrooms, numerous species have been identified as sources of bioactive chemicals. Moreover, there are unanswered queries regarding its safety, efficacy, critical issues that affect the future mushroom medicine development, that could jeopardize its usage in the twenty-first century.https://www.frontiersin.org/articles/10.3389/fphar.2022.925387/fullMedicinal mushroomsimmunomodulationradical scavengingantiviralimmune boosterscardioprotective |
| spellingShingle | Rishi Man Chugh Pooja Mittal Namratha MP Tanu Arora Tanima Bhattacharya Tanima Bhattacharya Hitesh Chopra Simona Cavalu Rupesh K. Gautam Fungal Mushrooms: A Natural Compound With Therapeutic Applications Frontiers in Pharmacology Medicinal mushrooms immunomodulation radical scavenging antiviral immune boosters cardioprotective |
| title | Fungal Mushrooms: A Natural Compound With Therapeutic Applications |
| title_full | Fungal Mushrooms: A Natural Compound With Therapeutic Applications |
| title_fullStr | Fungal Mushrooms: A Natural Compound With Therapeutic Applications |
| title_full_unstemmed | Fungal Mushrooms: A Natural Compound With Therapeutic Applications |
| title_short | Fungal Mushrooms: A Natural Compound With Therapeutic Applications |
| title_sort | fungal mushrooms a natural compound with therapeutic applications |
| topic | Medicinal mushrooms immunomodulation radical scavenging antiviral immune boosters cardioprotective |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.925387/full |
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