Virus-like particle – mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

Virus-like particle – mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection

Virus-Like Particles (VLPs) are nanostructures that share conformation and self-assembly properties with viruses, but lack a viral genome and therefore the infectious capacity. In this study, we produced VLPs by co-expression of VSV glycoprotein (VSV-G) and HIV structural proteins (Gag, Pol) that in...

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Bibliographic Details
Main Authors: Enrico Palermo, Magdalini Alexandridi, Daniele Di Carlo, Michela Muscolini, John Hiscott
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
virus like particle (VLP)
RIG-I
antiviral immune response
innate immunity
type-I IFN
viral infection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.1079926/full

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