Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla
Abstract 7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies have used standard Time-of-Flight (ToF) Magnetic Re...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-24832-z |
| _version_ | 1811186980687446016 |
|---|---|
| author | Christopher N. Osuafor Catarina Rua Andrew D. Mackinnon Marco Egle Philip Benjamin Daniel J. Tozer Christopher T. Rodgers Hugh S. Markus |
| author_facet | Christopher N. Osuafor Catarina Rua Andrew D. Mackinnon Marco Egle Philip Benjamin Daniel J. Tozer Christopher T. Rodgers Hugh S. Markus |
| author_sort | Christopher N. Osuafor |
| collection | DOAJ |
| description | Abstract 7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies have used standard Time-of-Flight (ToF) Magnetic Resonance Angiography (MRA). Whether the use of contrast enhancement improves perforating artery visualisation at 7 T remains unclear. In a prospective study, we compared standard ToF MRA with contrast-enhanced (CE) ToF MRA at 7 T for the visualisation of the lenticulostriate arteries (LSAs). Ten patients with symptomatic lacunar stroke were recruited (mean age, SD, 64 ± 9.9 years). Visualisation was assessed using a visual rating scale administered by two independent expert readers and length of the LSAs visible. Visualisation of the LSAs was improved with CE ToF MRA. The mean Visibility and Sharpness Score was higher for CE ToF MRA over standard ToF MRA (2.55 ± 0.64 vs. 1.75 ± 0.68; P = 0.0008). The mean length of LSA visualised was significantly longer with CE ToF MRA compared to standard ToF MRA (24.4 ± 4.5 vs. 21.9 ± 4.0 mm; P = 0.01). CE ToF MRA offers improved visualisation of the LSAs over standard ToF MRA. The addition of contrast may improve the ability to visualise cerebral small vessel disease arterial pathology. |
| first_indexed | 2024-04-11T13:55:28Z |
| format | Article |
| id | doaj.art-edec8c3a7f954c6e8ed75f0e4f82e61a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T13:55:28Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-edec8c3a7f954c6e8ed75f0e4f82e61a2022-12-22T04:20:22ZengNature PortfolioScientific Reports2045-23222022-11-011211910.1038/s41598-022-24832-zVisualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 TeslaChristopher N. Osuafor0Catarina Rua1Andrew D. Mackinnon2Marco Egle3Philip Benjamin4Daniel J. Tozer5Christopher T. Rodgers6Hugh S. Markus7Stroke Research Group, Department of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of CambridgeAtkinson Morley Regional Neuroscience Centre, St George’s University Hospitals NHS Foundation TrustStroke Research Group, Department of Clinical Neurosciences, University of CambridgeAtkinson Morley Regional Neuroscience Centre, St George’s University Hospitals NHS Foundation TrustStroke Research Group, Department of Clinical Neurosciences, University of CambridgeWolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of CambridgeStroke Research Group, Department of Clinical Neurosciences, University of CambridgeAbstract 7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease. Most studies have used standard Time-of-Flight (ToF) Magnetic Resonance Angiography (MRA). Whether the use of contrast enhancement improves perforating artery visualisation at 7 T remains unclear. In a prospective study, we compared standard ToF MRA with contrast-enhanced (CE) ToF MRA at 7 T for the visualisation of the lenticulostriate arteries (LSAs). Ten patients with symptomatic lacunar stroke were recruited (mean age, SD, 64 ± 9.9 years). Visualisation was assessed using a visual rating scale administered by two independent expert readers and length of the LSAs visible. Visualisation of the LSAs was improved with CE ToF MRA. The mean Visibility and Sharpness Score was higher for CE ToF MRA over standard ToF MRA (2.55 ± 0.64 vs. 1.75 ± 0.68; P = 0.0008). The mean length of LSA visualised was significantly longer with CE ToF MRA compared to standard ToF MRA (24.4 ± 4.5 vs. 21.9 ± 4.0 mm; P = 0.01). CE ToF MRA offers improved visualisation of the LSAs over standard ToF MRA. The addition of contrast may improve the ability to visualise cerebral small vessel disease arterial pathology.https://doi.org/10.1038/s41598-022-24832-z |
| spellingShingle | Christopher N. Osuafor Catarina Rua Andrew D. Mackinnon Marco Egle Philip Benjamin Daniel J. Tozer Christopher T. Rodgers Hugh S. Markus Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla Scientific Reports |
| title | Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla |
| title_full | Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla |
| title_fullStr | Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla |
| title_full_unstemmed | Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla |
| title_short | Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla |
| title_sort | visualisation of lenticulostriate arteries using contrast enhanced time of flight magnetic resonance angiography at 7 tesla |
| url | https://doi.org/10.1038/s41598-022-24832-z |
| work_keys_str_mv | AT christophernosuafor visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT catarinarua visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT andrewdmackinnon visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT marcoegle visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT philipbenjamin visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT danieljtozer visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT christophertrodgers visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla AT hughsmarkus visualisationoflenticulostriatearteriesusingcontrastenhancedtimeofflightmagneticresonanceangiographyat7tesla |