Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials
This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained v...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Polymers |
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| Online Access: | http://www.mdpi.com/2073-4360/10/10/1165 |
| _version_ | 1811295503241969664 |
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| author | Tobias Mai Karol Wolski Agnieszka Puciul-Malinowska Alexey Kopyshev Ralph Gräf Michael Bruns Szczepan Zapotoczny Andreas Taubert |
| author_facet | Tobias Mai Karol Wolski Agnieszka Puciul-Malinowska Alexey Kopyshev Ralph Gräf Michael Bruns Szczepan Zapotoczny Andreas Taubert |
| author_sort | Tobias Mai |
| collection | DOAJ |
| description | This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields. |
| first_indexed | 2024-04-13T05:33:26Z |
| format | Article |
| id | doaj.art-edee49011ace41c2803feb284405caec |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-04-13T05:33:26Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-edee49011ace41c2803feb284405caec2022-12-22T03:00:21ZengMDPI AGPolymers2073-43602018-10-011010116510.3390/polym10101165polym10101165Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in BiomaterialsTobias Mai0Karol Wolski1Agnieszka Puciul-Malinowska2Alexey Kopyshev3Ralph Gräf4Michael Bruns5Szczepan Zapotoczny6Andreas Taubert7Institute of Chemistry, University of Potsdam, D-14476 Potsdam, GermanyFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, PolandFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, PolandInstitute of Physics and Astronomy, University of Potsdam, D-14476 Potsdam, GermanyInstitute of Biochemistry and Biology, University of Potsdam, D-14476 Potsdam, GermanyInstitute for Applied Materials and Karlsruhe Nano Micro Facility (KNMF), Karlsruhe Institute of Technology, D-76344 Eggenstein-Leopoldshafen, GermanyFaculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, PolandInstitute of Chemistry, University of Potsdam, D-14476 Potsdam, GermanyThis article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.http://www.mdpi.com/2073-4360/10/10/1165polymer brushescalcium phosphatehydroxyapatitecarbonated apatitebone mimicbiocompatibilityDictyostelium discoideum |
| spellingShingle | Tobias Mai Karol Wolski Agnieszka Puciul-Malinowska Alexey Kopyshev Ralph Gräf Michael Bruns Szczepan Zapotoczny Andreas Taubert Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials Polymers polymer brushes calcium phosphate hydroxyapatite carbonated apatite bone mimic biocompatibility Dictyostelium discoideum |
| title | Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials |
| title_full | Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials |
| title_fullStr | Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials |
| title_full_unstemmed | Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials |
| title_short | Anionic Polymer Brushes for Biomimetic Calcium Phosphate Mineralization—A Surface with Application Potential in Biomaterials |
| title_sort | anionic polymer brushes for biomimetic calcium phosphate mineralization a surface with application potential in biomaterials |
| topic | polymer brushes calcium phosphate hydroxyapatite carbonated apatite bone mimic biocompatibility Dictyostelium discoideum |
| url | http://www.mdpi.com/2073-4360/10/10/1165 |
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