The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.

The Role of Indoleamine 2,3-Dioxygenase in Diethylnitrosamine-Induced Liver Carcinogenesis.

Indoleamine 2,3-dioxygenase (IDO), a tryptophan-catabolizing intracellular enzyme of the L-kynurenine pathway, causes preneoplastic cells and tumor cells to escape the immune system by inducing immune tolerance; this mechanism might be associated with the development and progression of human maligna...

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Main Authors: Yuhei Shibata, Takeshi Hara, Junji Nagano, Nobuhiko Nakamura, Tomohiko Ohno, Soranobu Ninomiya, Hiroyasu Ito, Takuji Tanaka, Kuniaki Saito, Mitsuru Seishima, Masahito Shimizu, Hisataka Moriwaki, Hisashi Tsurumi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4699706?pdf=render

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