Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90
Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2022-07-01
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| Series: | Journal of Epidemiology |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jea/32/7/32_JE20200399/_pdf |
| _version_ | 1811326174199021568 |
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| author | Aya Hirata Tomonori Okamura Takumi Hirata Daisuke Sugiyama Takayoshi Ohkubo Nagako Okuda Yoshikuni Kita Takehito Hayakawa Aya Kadota Keiko Kondo Katsuyuki Miura Akira Okayama Hirotsugu Ueshima |
| author_facet | Aya Hirata Tomonori Okamura Takumi Hirata Daisuke Sugiyama Takayoshi Ohkubo Nagako Okuda Yoshikuni Kita Takehito Hayakawa Aya Kadota Keiko Kondo Katsuyuki Miura Akira Okayama Hirotsugu Ueshima |
| author_sort | Aya Hirata |
| collection | DOAJ |
| description | Background: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population. Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years. Results: During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years. Conclusion: In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events. |
| first_indexed | 2024-04-13T14:45:39Z |
| format | Article |
| id | doaj.art-edf0107207b2404082487ac301cd8558 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-04-13T14:45:39Z |
| publishDate | 2022-07-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-edf0107207b2404082487ac301cd85582022-12-22T02:42:46ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922022-07-0132730331310.2188/jea.JE20200399Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90Aya Hirata0Tomonori Okamura1Takumi Hirata2Daisuke Sugiyama3Takayoshi Ohkubo4Nagako Okuda5Yoshikuni Kita6Takehito Hayakawa7Aya Kadota8Keiko Kondo9Katsuyuki Miura10Akira Okayama11Hirotsugu Ueshima12Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, JapanDepartment of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, JapanDepartment of Public Health, Hokkaido University Faculty of Medicine, Sapporo, JapanFaculty of Nursing and Medical Care, Keio University, Fujisawa, Kanagawa, JapanDepartment of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, JapanDepartment of Health and Nutrition, University of Human Arts and Sciences, Saitama, JapanTsuruga City University of Nursing, Fukui, JapanResearch Center for Social Studies of Health and Community, Ritsumeikan University, Kyoto, JapanDepartment of Public Health, Shiga University of Medical Science, Shiga, JapanDepartment of Public Health, Shiga University of Medical Science, Shiga, JapanDepartment of Public Health, Shiga University of Medical Science, Shiga, JapanResearch Institute of Strategy for Prevention, Tokyo, JapanDepartment of Public Health, Shiga University of Medical Science, Shiga, JapanBackground: Non-fasting triglycerides (TG) are considered a better predictor of cardiovascular disease (CVD) than fasting TG. However, the effect of non-fasting TG on fatal CVD events remains unclear. In the present study, we aimed to explore the relationship between non-fasting TG and CVD mortality in a Japanese general population. Methods: A total of 6,831 participants without a history of CVD, in which those who had a blood sampling over 8 hours or more after a meal were excluded, were followed for 18.0 years. We divided participants into seven groups according to non-fasting TG levels: ≤59 mg/dL, 60–89 mg/dL, 90–119 mg/dL, 120–149 mg/dL, 150–179 mg/dL, 180–209 mg/dL, and ≥210 mg/dL, and estimated the multivariable-adjusted hazard ratios (HRs) of each TG group for CVD mortality after adjusting for potential confounders, including high density lipoprotein cholesterol. Additionally, we performed analysis stratified by age <65 and ≥65 years. Results: During the follow-up period, 433 deaths due to CVD were detected. Compared with a non-fasting TG of 150–179 mg/dL, non-fasting TG ≥210 mg/dL was significantly associated with increased risk for CVD mortality (HR 1.56: 95% CI, 1.01–2.41). Additionally, lower levels of non-fasting TG were also significantly associated with increased risk for fatal CVD. In participants aged ≥65 years, lower levels of non-fasting TG had a stronger impact on increased risk for CVD mortality, while higher levels of non-fasting TG had a stronger impact in those aged <65 years. Conclusion: In a general Japanese population, we observed a U-shaped association between non-fasting TG and fatal CVD events.https://www.jstage.jst.go.jp/article/jea/32/7/32_JE20200399/_pdfnon-fasting triglyceridecardiovascular diseasemortalitygeneral populationjapan |
| spellingShingle | Aya Hirata Tomonori Okamura Takumi Hirata Daisuke Sugiyama Takayoshi Ohkubo Nagako Okuda Yoshikuni Kita Takehito Hayakawa Aya Kadota Keiko Kondo Katsuyuki Miura Akira Okayama Hirotsugu Ueshima Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 Journal of Epidemiology non-fasting triglyceride cardiovascular disease mortality general population japan |
| title | Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 |
| title_full | Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 |
| title_fullStr | Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 |
| title_full_unstemmed | Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 |
| title_short | Relationship Between Non-fasting Triglycerides and Cardiovascular Disease Mortality in a 20-year Follow-up Study of a Japanese General Population: NIPPON DATA90 |
| title_sort | relationship between non fasting triglycerides and cardiovascular disease mortality in a 20 year follow up study of a japanese general population nippon data90 |
| topic | non-fasting triglyceride cardiovascular disease mortality general population japan |
| url | https://www.jstage.jst.go.jp/article/jea/32/7/32_JE20200399/_pdf |
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