Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

Improved Mucoadhesion, Permeation and In Vitro Anticancer Potential of Synthesized Thiolated Acacia and Karaya Gum Combination: A Systematic Study

Thiolation of polymers is one of the most appropriate approaches to impart higher mechanical strength and mucoadhesion. Thiol modification of gum karaya and gum acacia was carried out by esterification with 80% thioglycolic acid. FTIR, DSC and XRD confirmed the completion of thiolation reaction. Ant...

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Bibliographic Details
Main Authors: Neha Munot, Ujjwala Kandekar, Chaitali Rikame, Abhinandan Patil, Poulomi Sengupta, Shabana Urooj, Anusha Bilal
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
mucoadhesion
thiolated gums
ivabradine HCl
buccal tablets
enhanced permeation
Online Access:https://www.mdpi.com/1420-3049/27/20/6829

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