A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE
The conventional practice of tick management is mainly focused on treating the animals and animal shed with commonly available chemical acaricides. Yet, this method only provides a limited degree of success with several inherited pitfalls, such as acaricidal residues in meat and milk, biomagnifica...
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| Format: | Article |
| Language: | English |
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West Bengal Veterinary Alumni Association
2024-04-01
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| Series: | Exploratory Animal and Medical Research |
| Subjects: | |
| Online Access: | https://animalmedicalresearch.org/Vol.14_Parasitology-Special-Issue_April_2024/A%20REVIEW%20ON%20TICK%20VACCINE%20-%20CURRENT%20STATUS.pdf |
| _version_ | 1797209932821430272 |
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| author | Manisha Abhijit Nandi |
| author_facet | Manisha Abhijit Nandi |
| author_sort | Manisha |
| collection | DOAJ |
| description | The conventional practice of tick management is mainly focused on treating the animals and
animal shed with commonly available chemical acaricides. Yet, this method only provides a limited degree
of success with several inherited pitfalls, such as acaricidal residues in meat and milk, biomagnification in
the food web, selection of drug-insensitive ticks, and negative environmental impact from chemical
residues. Vaccines provide an enticing alternative approach, but progress has stalled against these
tenacious hematophagous arthropods. After over 30 years of vaccine research against tick and tick-borne
pathogens, only a handful of native or recombinant antigen targets have been identified and evaluated as
single-antigen vaccines, with inconsistent efficacy. In contrast, multi-antigen vaccines targeting several
molecular functions may hold better potential for effective control in the field. However, challenges
remain in ensuring consistent protein purity and expression scales, proper post-translational modification,
and optimal immune responses. Therefore, epitope-based peptide vaccines that can stimulate protective
immune responses represent a promising approach for tick vaccine development. Additionally, mRNA
vaccines have recently emerged as an alternative vaccine platform with potential benefits in potency,
speed of development, cost-effectiveness, and safety. Research continues to unlock new immunological
intricacies and opportunities within ticks. Novel vaccine strategies may achieve a pivotal breakthrough
against these pervasive arachnids and the dangerous diseases they spread.
|
| first_indexed | 2024-04-24T10:02:34Z |
| format | Article |
| id | doaj.art-edf5de7f15a04566919a29fcb9e282f9 |
| institution | Directory Open Access Journal |
| issn | 2277-470X 2319-247X |
| language | English |
| last_indexed | 2024-04-24T10:02:34Z |
| publishDate | 2024-04-01 |
| publisher | West Bengal Veterinary Alumni Association |
| record_format | Article |
| series | Exploratory Animal and Medical Research |
| spelling | doaj.art-edf5de7f15a04566919a29fcb9e282f92024-04-13T06:51:04ZengWest Bengal Veterinary Alumni AssociationExploratory Animal and Medical Research2277-470X2319-247X2024-04-0114Parasitology Spl.101710.52635/eamr/14(S1)10-17A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVEManisha0Abhijit Nandi1Division of Parasitology, ICAR-IVRI, Bareilly, Uttar Pradesh, IndiaDepartment of Veterinary Parasitology, WBUAFS, Belgachia, Kolkata, IndiaThe conventional practice of tick management is mainly focused on treating the animals and animal shed with commonly available chemical acaricides. Yet, this method only provides a limited degree of success with several inherited pitfalls, such as acaricidal residues in meat and milk, biomagnification in the food web, selection of drug-insensitive ticks, and negative environmental impact from chemical residues. Vaccines provide an enticing alternative approach, but progress has stalled against these tenacious hematophagous arthropods. After over 30 years of vaccine research against tick and tick-borne pathogens, only a handful of native or recombinant antigen targets have been identified and evaluated as single-antigen vaccines, with inconsistent efficacy. In contrast, multi-antigen vaccines targeting several molecular functions may hold better potential for effective control in the field. However, challenges remain in ensuring consistent protein purity and expression scales, proper post-translational modification, and optimal immune responses. Therefore, epitope-based peptide vaccines that can stimulate protective immune responses represent a promising approach for tick vaccine development. Additionally, mRNA vaccines have recently emerged as an alternative vaccine platform with potential benefits in potency, speed of development, cost-effectiveness, and safety. Research continues to unlock new immunological intricacies and opportunities within ticks. Novel vaccine strategies may achieve a pivotal breakthrough against these pervasive arachnids and the dangerous diseases they spread. https://animalmedicalresearch.org/Vol.14_Parasitology-Special-Issue_April_2024/A%20REVIEW%20ON%20TICK%20VACCINE%20-%20CURRENT%20STATUS.pdftick vaccinecurrent statusnovel concepts |
| spellingShingle | Manisha Abhijit Nandi A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE Exploratory Animal and Medical Research tick vaccine current status novel concepts |
| title | A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE |
| title_full | A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE |
| title_fullStr | A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE |
| title_full_unstemmed | A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE |
| title_short | A REVIEW ON TICK VACCINE - CURRENT STATUS AND FUTURE PROSPECTIVE |
| title_sort | review on tick vaccine current status and future prospective |
| topic | tick vaccine current status novel concepts |
| url | https://animalmedicalresearch.org/Vol.14_Parasitology-Special-Issue_April_2024/A%20REVIEW%20ON%20TICK%20VACCINE%20-%20CURRENT%20STATUS.pdf |
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