Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis
Background The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SA...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-05-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/8/2/00056-2022.full |
| _version_ | 1797809469330030592 |
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| author | Christopher C. Huntley Ketan Patel Shahnoor-E-Salam Bil Bushra Farah Mobeen Michael N. Armitage Anita Pye Chloe B. Knight Alyaa Mostafa Marie Kershaw Aishah Z. Mughal Emily McKemey Alice M. Turner P. Sherwood Burge Gareth I. Walters |
| author_facet | Christopher C. Huntley Ketan Patel Shahnoor-E-Salam Bil Bushra Farah Mobeen Michael N. Armitage Anita Pye Chloe B. Knight Alyaa Mostafa Marie Kershaw Aishah Z. Mughal Emily McKemey Alice M. Turner P. Sherwood Burge Gareth I. Walters |
| author_sort | Christopher C. Huntley |
| collection | DOAJ |
| description | Background
The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SARS and MERS may provide a model for predicting the long-term pulmonary consequences of COVID-19.
Methods
This systematic review and meta-analysis aims to describe and compare the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19. Meta-analysis of PFT parameters (DerSimonian and Laird random-effects model) and proportion of CT features (Freeman-Tukey transformation random-effects model) were performed.
Findings
Persistent reduction in the diffusing capacity for carbon monoxide following SARS and COVID-19 infection is seen at 6 months follow-up, and 12 months after MERS. Other PFT parameters recover in this time. 6 months after SARS and COVID-19, ground-glass opacity, linear opacities and reticulation persist in over 30% of patients; honeycombing and traction dilatation are reported less often. Severe/critical COVID-19 infection leads to greater CT and PFT abnormality compared to mild/moderate infection.
Interpretation
Persistent diffusion defects suggestive of parenchymal lung injury occur after SARS, MERS and COVID-19 infection, but improve over time. After COVID-19 infection, CT features are suggestive of persistent parenchymal lung injury, in keeping with a post-COVID-19 interstitial lung syndrome. It is yet to be determined if this is a regressive or progressive disease. |
| first_indexed | 2024-03-13T06:53:16Z |
| format | Article |
| id | doaj.art-edf5e6d572b14fbc9d92eb52fdd24202 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:53:16Z |
| publishDate | 2022-05-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-edf5e6d572b14fbc9d92eb52fdd242022023-06-07T13:30:09ZengEuropean Respiratory SocietyERJ Open Research2312-05412022-05-018210.1183/23120541.00056-202200056-2022Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysisChristopher C. Huntley0Ketan Patel1Shahnoor-E-Salam Bil Bushra2Farah Mobeen3Michael N. Armitage4Anita Pye5Chloe B. Knight6Alyaa Mostafa7Marie Kershaw8Aishah Z. Mughal9Emily McKemey10Alice M. Turner11P. Sherwood Burge12Gareth I. Walters13 Occupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK University of Birmingham, Birmingham, UK UHB NHS Foundation Trust, Birmingham, UK University Hospitals Coventry and Warwickshire NHS Trust, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK University of Birmingham, Birmingham, UK University of Birmingham, Birmingham, UK UHB NHS Foundation Trust, Birmingham, UK University of Birmingham, Birmingham, UK UHB NHS Foundation Trust, Birmingham, UK Institute of Applied Health Research, University of Birmingham, Birmingham, UK Occupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK Occupational and Interstitial Lung Disease Services, University Hospitals Birmingham (UHB) NHS Foundation Trust, Birmingham, UK Background The COVID-19 pandemic follows severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus epidemics. Some survivors of COVID-19 infection experience persistent respiratory symptoms, yet their cause and natural history remain unclear. Follow-up after SARS and MERS may provide a model for predicting the long-term pulmonary consequences of COVID-19. Methods This systematic review and meta-analysis aims to describe and compare the longitudinal pulmonary function test (PFT) and computed tomography (CT) features of patients recovering from SARS, MERS and COVID-19. Meta-analysis of PFT parameters (DerSimonian and Laird random-effects model) and proportion of CT features (Freeman-Tukey transformation random-effects model) were performed. Findings Persistent reduction in the diffusing capacity for carbon monoxide following SARS and COVID-19 infection is seen at 6 months follow-up, and 12 months after MERS. Other PFT parameters recover in this time. 6 months after SARS and COVID-19, ground-glass opacity, linear opacities and reticulation persist in over 30% of patients; honeycombing and traction dilatation are reported less often. Severe/critical COVID-19 infection leads to greater CT and PFT abnormality compared to mild/moderate infection. Interpretation Persistent diffusion defects suggestive of parenchymal lung injury occur after SARS, MERS and COVID-19 infection, but improve over time. After COVID-19 infection, CT features are suggestive of persistent parenchymal lung injury, in keeping with a post-COVID-19 interstitial lung syndrome. It is yet to be determined if this is a regressive or progressive disease.http://openres.ersjournals.com/content/8/2/00056-2022.full |
| spellingShingle | Christopher C. Huntley Ketan Patel Shahnoor-E-Salam Bil Bushra Farah Mobeen Michael N. Armitage Anita Pye Chloe B. Knight Alyaa Mostafa Marie Kershaw Aishah Z. Mughal Emily McKemey Alice M. Turner P. Sherwood Burge Gareth I. Walters Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis ERJ Open Research |
| title | Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis |
| title_full | Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis |
| title_fullStr | Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis |
| title_full_unstemmed | Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis |
| title_short | Pulmonary function test and computed tomography features during follow-up after SARS, MERS and COVID-19: a systematic review and meta-analysis |
| title_sort | pulmonary function test and computed tomography features during follow up after sars mers and covid 19 a systematic review and meta analysis |
| url | http://openres.ersjournals.com/content/8/2/00056-2022.full |
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