Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects
Gastric cancer is one of the most serious malignant tumor and threatens the health of people worldwide. Its heterogeneity leaves many clinical problems unsolved. To treat it effectively, we need to explore its heterogeneity. Single-cell transcriptome sequencing, or single-cell RNA sequencing (scRNA-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1074268/full |
| _version_ | 1797820263583186944 |
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| author | Gaohua Deng Xu Zhang Yonglan Chen Sicheng Liang Sha Liu Zehui Yu Muhan Lü |
| author_facet | Gaohua Deng Xu Zhang Yonglan Chen Sicheng Liang Sha Liu Zehui Yu Muhan Lü |
| author_sort | Gaohua Deng |
| collection | DOAJ |
| description | Gastric cancer is one of the most serious malignant tumor and threatens the health of people worldwide. Its heterogeneity leaves many clinical problems unsolved. To treat it effectively, we need to explore its heterogeneity. Single-cell transcriptome sequencing, or single-cell RNA sequencing (scRNA-seq), reveals the complex biological composition and molecular characteristics of gastric cancer at the level of individual cells, which provides a new perspective for understanding the heterogeneity of gastric cancer. In this review, we first introduce the current procedure of scRNA-seq, and discuss the advantages and limitations of scRNA-seq. We then elaborate on the research carried out with scRNA-seq in gastric cancer in recent years, and describe how it reveals cell heterogeneity, the tumor microenvironment, oncogenesis and metastasis, as well as drug response in to gastric cancer, to facilitate early diagnosis, individualized therapy, and prognosis evaluation. |
| first_indexed | 2024-03-13T09:35:55Z |
| format | Article |
| id | doaj.art-edf6208e78ca42a588ae76db638b084d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T09:35:55Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-edf6208e78ca42a588ae76db638b084d2023-05-25T16:21:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-05-011310.3389/fonc.2023.10742681074268Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospectsGaohua Deng0Xu Zhang1Yonglan Chen2Sicheng Liang3Sha Liu4Zehui Yu5Muhan Lü6Department of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaLaboratory Animal Center, Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Gastroenterology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaGastric cancer is one of the most serious malignant tumor and threatens the health of people worldwide. Its heterogeneity leaves many clinical problems unsolved. To treat it effectively, we need to explore its heterogeneity. Single-cell transcriptome sequencing, or single-cell RNA sequencing (scRNA-seq), reveals the complex biological composition and molecular characteristics of gastric cancer at the level of individual cells, which provides a new perspective for understanding the heterogeneity of gastric cancer. In this review, we first introduce the current procedure of scRNA-seq, and discuss the advantages and limitations of scRNA-seq. We then elaborate on the research carried out with scRNA-seq in gastric cancer in recent years, and describe how it reveals cell heterogeneity, the tumor microenvironment, oncogenesis and metastasis, as well as drug response in to gastric cancer, to facilitate early diagnosis, individualized therapy, and prognosis evaluation.https://www.frontiersin.org/articles/10.3389/fonc.2023.1074268/fullsingle-cell RNA sequencinggastric cancertumor heterogeneityoncogenesisindividualized therapy |
| spellingShingle | Gaohua Deng Xu Zhang Yonglan Chen Sicheng Liang Sha Liu Zehui Yu Muhan Lü Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects Frontiers in Oncology single-cell RNA sequencing gastric cancer tumor heterogeneity oncogenesis individualized therapy |
| title | Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects |
| title_full | Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects |
| title_fullStr | Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects |
| title_full_unstemmed | Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects |
| title_short | Single-cell transcriptome sequencing reveals heterogeneity of gastric cancer: progress and prospects |
| title_sort | single cell transcriptome sequencing reveals heterogeneity of gastric cancer progress and prospects |
| topic | single-cell RNA sequencing gastric cancer tumor heterogeneity oncogenesis individualized therapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1074268/full |
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