<i>Hops/Tmub1</i> Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis

<i>Hops/Tmub1</i> Heterozygous Mouse Shows Haploinsufficiency Effect in Influencing p53-Mediated Apoptosis

HOPS is a ubiquitin-like protein implicated in many aspects of cellular function including the regulation of mitotic activity, proliferation, and cellular stress responses. In this study, we focused on the complex relationship between HOPS and the tumor suppressor p53, investigating both transcripti...

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Bibliographic Details
Main Authors: Simona Ferracchiato, Nicola Di-Iacovo, Damiano Scopetti, Danilo Piobbico, Marilena Castelli, Stefania Pieroni, Marco Gargaro, Giorgia Manni, Stefano Brancorsini, Maria Agnese Della-Fazia, Giuseppe Servillo
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Hops/Tmub1</i>
heterozygous mouse
p53
apoptosis
DNA-damage response
haploinsufficiency
Online Access:https://www.mdpi.com/1422-0067/22/13/7186

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