Cytoplasmic forces functionally reorganize nuclear condensates in oocytes
Cytoskeletal activity generates mechanical forces known to agitate and displace membrane-bound organelles in the cytoplasm. In oocytes, Al Jord et al. discover that these cytoplasmic forces functionally remodel nuclear RNA-processing condensates across scales for developmental success.
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32675-5 |
| _version_ | 1798032116410220544 |
|---|---|
| author | Adel Al Jord Gaëlle Letort Soline Chanet Feng-Ching Tsai Christophe Antoniewski Adrien Eichmuller Christelle Da Silva Jean-René Huynh Nir S. Gov Raphaël Voituriez Marie-Émilie Terret Marie-Hélène Verlhac |
| author_facet | Adel Al Jord Gaëlle Letort Soline Chanet Feng-Ching Tsai Christophe Antoniewski Adrien Eichmuller Christelle Da Silva Jean-René Huynh Nir S. Gov Raphaël Voituriez Marie-Émilie Terret Marie-Hélène Verlhac |
| author_sort | Adel Al Jord |
| collection | DOAJ |
| description | Cytoskeletal activity generates mechanical forces known to agitate and displace membrane-bound organelles in the cytoplasm. In oocytes, Al Jord et al. discover that these cytoplasmic forces functionally remodel nuclear RNA-processing condensates across scales for developmental success. |
| first_indexed | 2024-04-11T20:07:36Z |
| format | Article |
| id | doaj.art-edf7a3701dba4bb2be0ace4d6b35c57c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T20:07:36Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-edf7a3701dba4bb2be0ace4d6b35c57c2022-12-22T04:05:16ZengNature PortfolioNature Communications2041-17232022-08-0113111910.1038/s41467-022-32675-5Cytoplasmic forces functionally reorganize nuclear condensates in oocytesAdel Al Jord0Gaëlle Letort1Soline Chanet2Feng-Ching Tsai3Christophe Antoniewski4Adrien Eichmuller5Christelle Da Silva6Jean-René Huynh7Nir S. Gov8Raphaël Voituriez9Marie-Émilie Terret10Marie-Hélène Verlhac11Center for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLLaboratoire Physico Chimie Curie, Institut Curie, CNRS, Université PSLARTbio Bioinformatics Analysis Facility, IBPS, CNRS, Sorbonne Université, Institut Français de BioinformatiqueCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLDepartment of Chemical and Biological Physics, Weizmann Institute of ScienceUniversité Pierre et Marie Curie-UPMC, CNRS, Sorbonne UniversitéCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCenter for Interdisciplinary Research in Biology, Collège de France, CNRS, INSERM, Université PSLCytoskeletal activity generates mechanical forces known to agitate and displace membrane-bound organelles in the cytoplasm. In oocytes, Al Jord et al. discover that these cytoplasmic forces functionally remodel nuclear RNA-processing condensates across scales for developmental success.https://doi.org/10.1038/s41467-022-32675-5 |
| spellingShingle | Adel Al Jord Gaëlle Letort Soline Chanet Feng-Ching Tsai Christophe Antoniewski Adrien Eichmuller Christelle Da Silva Jean-René Huynh Nir S. Gov Raphaël Voituriez Marie-Émilie Terret Marie-Hélène Verlhac Cytoplasmic forces functionally reorganize nuclear condensates in oocytes Nature Communications |
| title | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| title_full | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| title_fullStr | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| title_full_unstemmed | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| title_short | Cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| title_sort | cytoplasmic forces functionally reorganize nuclear condensates in oocytes |
| url | https://doi.org/10.1038/s41467-022-32675-5 |
| work_keys_str_mv | AT adelaljord cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT gaelleletort cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT solinechanet cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT fengchingtsai cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT christopheantoniewski cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT adrieneichmuller cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT christelledasilva cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT jeanrenehuynh cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT nirsgov cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT raphaelvoituriez cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT marieemilieterret cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes AT marieheleneverlhac cytoplasmicforcesfunctionallyreorganizenuclearcondensatesinoocytes |