Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes

Poor outcome of pediatric B-cell acute lymphoblastic leukemia associated with high level of CRLF2 gene expression in distinct molecular subtypes

BackgroundOverexpression of the cytokine receptor-like factor 2 (CRLF2) gene is the most common feature in the Philadelphia chromosome (Ph)-like subtype of B-cell acute lymphoblastic leukemia (B-ALL). However, the predictive value of CRLF2 overexpression for the prognosis of pediatric B-ALL patients...

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Bibliographic Details
Main Authors: Danna Lin, Keyan Yang, Lihua Yu, Lulu Huang, Xiaorong Lai, Li Wu, Xiayu Xia, Jingwen Zhang, Qinlong Zheng, Lihua Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
B-ALL
CRLF2
Ph-like
pediatric
leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1256054/full

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