K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model.
BACKGROUND:K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. OBJECTIVES:This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3479105?pdf=render |
| _version_ | 1828803487963545600 |
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| author | Hideo Yoshida Yuka Ashikawa Shinsuke Itoh Takashi Nakagawa Akimune Asanuma Sohei Tanabe Yoshihiro Inoue Hiroyoshi Hidaka |
| author_facet | Hideo Yoshida Yuka Ashikawa Shinsuke Itoh Takashi Nakagawa Akimune Asanuma Sohei Tanabe Yoshihiro Inoue Hiroyoshi Hidaka |
| author_sort | Hideo Yoshida |
| collection | DOAJ |
| description | BACKGROUND:K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. OBJECTIVES:This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombotic cerebral infarction model. METHODS AND RESULTS:We investigated the effects of oral preadministration of PDE3 inhibitors in a rat stroke model established by photothrombotic middle cerebral artery (MCA) occlusion. K-134 significantly prolonged MCA occlusion time at doses >10 mg/kg, and reduced cerebral infarct size at 30 mg/kg in the stroke model (n = 12, 87.5±5.6 vs. 126.8±7.5 mm(3), P<0.01), indicating its potent antithrombotic effect. On the other hand, the effects of cilostazol on MCA occlusion time and cerebral infarct size are relatively weak even at the high dosage of 300 mg/kg. Furthermore, K-134 blocked rat platelet aggregation more potently than cilostazol in vitro. Also in an arteriovenous shunt thrombosis model, K-134 showed an antithrombotic effect greater than cilostazol. CONCLUSIONS:These findings suggest that K-134, which has strong antithrombotic activity, is a promising drug for prevention of cerebral infarction associated with platelet hyperaggregability. |
| first_indexed | 2024-12-12T07:24:17Z |
| format | Article |
| id | doaj.art-edf9434b38684428a37d1136decbec79 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T07:24:17Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-edf9434b38684428a37d1136decbec792022-12-22T00:33:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4643210.1371/journal.pone.0046432K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model.Hideo YoshidaYuka AshikawaShinsuke ItohTakashi NakagawaAkimune AsanumaSohei TanabeYoshihiro InoueHiroyoshi HidakaBACKGROUND:K-134 is a more potent antiplatelet drug with a selective inhibitory effect on phosphodiesterase 3 (PDE3) compared with its analogue, cilostazol. OBJECTIVES:This study was performed to compare the ameliorating effects of K-134 and cilostazol on brain damage in an experimental photothrombotic cerebral infarction model. METHODS AND RESULTS:We investigated the effects of oral preadministration of PDE3 inhibitors in a rat stroke model established by photothrombotic middle cerebral artery (MCA) occlusion. K-134 significantly prolonged MCA occlusion time at doses >10 mg/kg, and reduced cerebral infarct size at 30 mg/kg in the stroke model (n = 12, 87.5±5.6 vs. 126.8±7.5 mm(3), P<0.01), indicating its potent antithrombotic effect. On the other hand, the effects of cilostazol on MCA occlusion time and cerebral infarct size are relatively weak even at the high dosage of 300 mg/kg. Furthermore, K-134 blocked rat platelet aggregation more potently than cilostazol in vitro. Also in an arteriovenous shunt thrombosis model, K-134 showed an antithrombotic effect greater than cilostazol. CONCLUSIONS:These findings suggest that K-134, which has strong antithrombotic activity, is a promising drug for prevention of cerebral infarction associated with platelet hyperaggregability.http://europepmc.org/articles/PMC3479105?pdf=render |
| spellingShingle | Hideo Yoshida Yuka Ashikawa Shinsuke Itoh Takashi Nakagawa Akimune Asanuma Sohei Tanabe Yoshihiro Inoue Hiroyoshi Hidaka K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. PLoS ONE |
| title | K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. |
| title_full | K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. |
| title_fullStr | K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. |
| title_full_unstemmed | K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. |
| title_short | K-134, a phosphodiesterase 3 inhibitor, prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model. |
| title_sort | k 134 a phosphodiesterase 3 inhibitor prevents brain damage by inhibiting thrombus formation in a rat cerebral infarction model |
| url | http://europepmc.org/articles/PMC3479105?pdf=render |
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