Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review
Background: Many COVID-19 survivors experience persistent COVID-19 related cardiac abnormalities weeks to months after recovery from acute SARS-CoV-2 infection. Non-invasive cardiac magnetic resonance (CMR) imaging is an important tool of choice for clinical diagnosis of cardiac dysfunctions. In thi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-11-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/23/12/10.31083/j.rcm2312389 |
| _version_ | 1828085590799679488 |
|---|---|
| author | Montek S Boparai Benjamin Musheyev Umair Khan Tejaswi Koduru Jared Hinson Hal A Skopicki Tim Q Duong |
| author_facet | Montek S Boparai Benjamin Musheyev Umair Khan Tejaswi Koduru Jared Hinson Hal A Skopicki Tim Q Duong |
| author_sort | Montek S Boparai |
| collection | DOAJ |
| description | Background: Many COVID-19 survivors experience persistent COVID-19 related cardiac abnormalities weeks to months after recovery from acute SARS-CoV-2 infection. Non-invasive cardiac magnetic resonance (CMR) imaging is an important tool of choice for clinical diagnosis of cardiac dysfunctions. In this systematic review, we analyzed the CMR findings and biomarkers of COVID-19 related cardiac sequela after SARS-CoV-2 infection. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), we conducted a systematic review of studies that assessed COVID-19 related cardiac abnormalities using cardiovascular magnetic resonance imaging. A total of 21 cross-sectional, case-control, and cohort studies were included in the analyses. Results: Ten studies reported CMR results <3 months after SARS-CoV-2 infection and 11 studies >3 months after SARS-CoV-2 infection. Abnormal T1, abnormal T2, elevated extracellular volume, late gadolinium enhancement and myocarditis was reported less frequently in the >3-month studies. Eight studies reported an association between biomarkers and CMR findings. Elevated troponin was associated with CMR pathology in 5/6 studies, C-reactive protein in 3/5 studies, N-terminal pro-brain natriuretic peptide in 1/2 studies, and lactate dehydrogenase and D-dimer in a single study. The rate of myocarditis via CMR was 18% (154/868) across all studies. Most SARS-CoV-2 associated CMR abnormalities resolved over time. Conclusions: There were CMR abnormalities associated with SARS-CoV-2 infection and most abnormalities resolved over time. A panel of cardiac injury and inflammatory biomarkers could be useful in identifying patients who are likely to present with abnormal CMR pathology after COVID-19. Multiple mechanisms are likely responsible for COVID-19 induced cardiac abnormalities. |
| first_indexed | 2024-04-11T04:41:49Z |
| format | Article |
| id | doaj.art-edfa97cc6992479ebef1d1f8095e8775 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-11T04:41:49Z |
| publishDate | 2022-11-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-edfa97cc6992479ebef1d1f8095e87752022-12-28T05:34:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-11-01231238910.31083/j.rcm2312389S1530-6550(22)00744-XCardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic ReviewMontek S Boparai0Benjamin Musheyev1Umair Khan2Tejaswi Koduru3Jared Hinson4Hal A Skopicki5Tim Q Duong6Department of Radiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USARenaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USARenaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USADepartment of Radiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USARenaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USADepartment of Medicine, Division of Cardiology, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY 11794, USADepartment of Radiology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USABackground: Many COVID-19 survivors experience persistent COVID-19 related cardiac abnormalities weeks to months after recovery from acute SARS-CoV-2 infection. Non-invasive cardiac magnetic resonance (CMR) imaging is an important tool of choice for clinical diagnosis of cardiac dysfunctions. In this systematic review, we analyzed the CMR findings and biomarkers of COVID-19 related cardiac sequela after SARS-CoV-2 infection. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), we conducted a systematic review of studies that assessed COVID-19 related cardiac abnormalities using cardiovascular magnetic resonance imaging. A total of 21 cross-sectional, case-control, and cohort studies were included in the analyses. Results: Ten studies reported CMR results <3 months after SARS-CoV-2 infection and 11 studies >3 months after SARS-CoV-2 infection. Abnormal T1, abnormal T2, elevated extracellular volume, late gadolinium enhancement and myocarditis was reported less frequently in the >3-month studies. Eight studies reported an association between biomarkers and CMR findings. Elevated troponin was associated with CMR pathology in 5/6 studies, C-reactive protein in 3/5 studies, N-terminal pro-brain natriuretic peptide in 1/2 studies, and lactate dehydrogenase and D-dimer in a single study. The rate of myocarditis via CMR was 18% (154/868) across all studies. Most SARS-CoV-2 associated CMR abnormalities resolved over time. Conclusions: There were CMR abnormalities associated with SARS-CoV-2 infection and most abnormalities resolved over time. A panel of cardiac injury and inflammatory biomarkers could be useful in identifying patients who are likely to present with abnormal CMR pathology after COVID-19. Multiple mechanisms are likely responsible for COVID-19 induced cardiac abnormalities.https://www.imrpress.com/journal/RCM/23/12/10.31083/j.rcm2312389mrisars-cov-2myocarditispost-acute covid-19 symptomstroponin |
| spellingShingle | Montek S Boparai Benjamin Musheyev Umair Khan Tejaswi Koduru Jared Hinson Hal A Skopicki Tim Q Duong Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review Reviews in Cardiovascular Medicine mri sars-cov-2 myocarditis post-acute covid-19 symptoms troponin |
| title | Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review |
| title_full | Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review |
| title_fullStr | Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review |
| title_full_unstemmed | Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review |
| title_short | Cardiac Magnetic Resonance Imaging of COVID-19-Associated Cardiac Sequelae: A Systematic Review |
| title_sort | cardiac magnetic resonance imaging of covid 19 associated cardiac sequelae a systematic review |
| topic | mri sars-cov-2 myocarditis post-acute covid-19 symptoms troponin |
| url | https://www.imrpress.com/journal/RCM/23/12/10.31083/j.rcm2312389 |
| work_keys_str_mv | AT monteksboparai cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT benjaminmusheyev cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT umairkhan cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT tejaswikoduru cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT jaredhinson cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT halaskopicki cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview AT timqduong cardiacmagneticresonanceimagingofcovid19associatedcardiacsequelaeasystematicreview |