Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration
Purpose: To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Ophthalmology |
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| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=12;spage=1790;epage=1795;aulast=Nagpal |
| _version_ | 1818451685420302336 |
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| author | Manish Nagpal Jayesh Khandelwal Rakesh Juneja Navneet Mehrotra |
| author_facet | Manish Nagpal Jayesh Khandelwal Rakesh Juneja Navneet Mehrotra |
| author_sort | Manish Nagpal |
| collection | DOAJ |
| description | Purpose: To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospective, interventional study. Methods: Patients with wet AMD were treated with 3 injections of intravitreal anti-VEGF at monthly intervals for 3 months and followed at 1, 2, 3, and 6 months postinjection. Using “overlay” features, morphologic characteristics of OCTA at the site of choroidal neovascular membrane (CNVM) lesion were analyzed and correlated functionally with MP3. Data were collected including visual acuity at presentation and follow-up with multimodal imaging features, treatment details, complications (if any), and treatment given for that complication. Descriptive observational analysis and paired t-test was used to compare the appearance of the neovascular network on OCTA imaging with retinal sensitivity on MP3. Results: OCTA in the pretreatment phase revealed CNVM as an abnormal vascular network arising from the choroid and invading the subretinal space. On MP3, decreased retinal sensitivity was observed corresponding to the area of CNVM. Post-treatment, OCTA revealed reduction in abnormal vascular network in 51 (91.07%) eyes that correlated with increased retinal sensitivity at the corresponding area on MP3. Statistical analysis showed baseline mean retinal sensitivity at the site of CNVM as 320.07 dB, which improved to 521.53 and 730.20 dB at 1 and 3 months postinjection follow-up, respectively. Conclusion: Combining the findings of OCTA and MP3 using “overlay” features gives us precise information of structure–function correlation at presentation and also in response to treatment. It also helps to improve patient's compliance, confidence to treatment, and their understanding of the disease process as well. |
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| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-12-14T21:11:07Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-edfacc9cff7e409daffb3df1eb5b33e52022-12-21T22:47:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892018-01-0166121790179510.4103/ijo.IJO_866_18Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degenerationManish NagpalJayesh KhandelwalRakesh JunejaNavneet MehrotraPurpose: To evaluate and correlate the functional treatment response using microperimetry (MP3) with the morphological findings on optical coherence tomography angiography (OCTA) in wet AMD pre- and post-treatment with anti-vascular endothelial growth factor (VEGF). This was a single-centre prospective, interventional study. Methods: Patients with wet AMD were treated with 3 injections of intravitreal anti-VEGF at monthly intervals for 3 months and followed at 1, 2, 3, and 6 months postinjection. Using “overlay” features, morphologic characteristics of OCTA at the site of choroidal neovascular membrane (CNVM) lesion were analyzed and correlated functionally with MP3. Data were collected including visual acuity at presentation and follow-up with multimodal imaging features, treatment details, complications (if any), and treatment given for that complication. Descriptive observational analysis and paired t-test was used to compare the appearance of the neovascular network on OCTA imaging with retinal sensitivity on MP3. Results: OCTA in the pretreatment phase revealed CNVM as an abnormal vascular network arising from the choroid and invading the subretinal space. On MP3, decreased retinal sensitivity was observed corresponding to the area of CNVM. Post-treatment, OCTA revealed reduction in abnormal vascular network in 51 (91.07%) eyes that correlated with increased retinal sensitivity at the corresponding area on MP3. Statistical analysis showed baseline mean retinal sensitivity at the site of CNVM as 320.07 dB, which improved to 521.53 and 730.20 dB at 1 and 3 months postinjection follow-up, respectively. Conclusion: Combining the findings of OCTA and MP3 using “overlay” features gives us precise information of structure–function correlation at presentation and also in response to treatment. It also helps to improve patient's compliance, confidence to treatment, and their understanding of the disease process as well.http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=12;spage=1790;epage=1795;aulast=NagpalAge-related macular degenerationanti-VEGFmicroperimetryneovascular networkoptical coherence tomography angiographyretinal sensitivity |
| spellingShingle | Manish Nagpal Jayesh Khandelwal Rakesh Juneja Navneet Mehrotra Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration Indian Journal of Ophthalmology Age-related macular degeneration anti-VEGF microperimetry neovascular network optical coherence tomography angiography retinal sensitivity |
| title | Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration |
| title_full | Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration |
| title_fullStr | Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration |
| title_full_unstemmed | Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration |
| title_short | Correlation of optical coherence tomography angiography and microperimetry (MP3) features in wet age-related macular degeneration |
| title_sort | correlation of optical coherence tomography angiography and microperimetry mp3 features in wet age related macular degeneration |
| topic | Age-related macular degeneration anti-VEGF microperimetry neovascular network optical coherence tomography angiography retinal sensitivity |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2018;volume=66;issue=12;spage=1790;epage=1795;aulast=Nagpal |
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