KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells

<p>Abstract</p> <p>Background</p> <p>We previously described a sub-population of epithelial ovarian cancer (EOC) cells with a functional TLR-4/MyD88/NF-κB pathway (Type I EOC cells), which confers the capacity to respond to Paclitaxel, a known TLR-4 ligand, by enhancing...

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Bibliographic Details
Main Authors: Woessner Richard, Tytler Ewan M, Xie Yanhua, Kim Ki, Mor Gil, Alvero Ayesha B
Format: Article
Language:English
Published: BMC 2009-07-01
Series:Journal of Translational Medicine
Online Access:http://www.translational-medicine.com/content/7/1/63