Gene Therapy Advances: A Meta-Analysis of AAV Usage in Clinical Settings
Adeno-associated viruses (AAVs) are the safest and most effective gene delivery vehicles to drive long-term transgene expression in gene therapy. While animal studies have shown promising results, the translatability of AAVs into clinical settings has been partly limited due to their restricted gene...
Main Authors: | Hau Kiu Edna Au, Mark Isalan, Michal Mielcarek |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-02-01
|
Series: | Frontiers in Medicine |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.809118/full |
Similar Items
-
A minimal region of the HSP90AB1 promoter is suitable for ubiquitous expression in different somatic tissues with applicability for gene therapy
by: Michal Mielcarek, et al.
Published: (2023-04-01) -
Hydroxylation of N-acetylneuraminic Acid Influences the in vivo Tropism of N-linked Sialic Acid-Binding Adeno-Associated Viruses AAV1, AAV5, and AAV6
by: Estrella Lopez-Gordo, et al.
Published: (2021-12-01) -
A shared mechanism of muscle wasting in cancer and Huntington's disease
by: Michal Mielcarek, et al.
Published: (2015-12-01) -
Kinetin stimulates differentiation of C2C12 myoblasts.
by: Michal Mielcarek, et al.
Published: (2021-01-01) -
Neuro-Cardio Mechanisms in Huntington’s Disease and Other Neurodegenerative Disorders
by: Bethan J. Critchley, et al.
Published: (2018-05-01)