Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment

Antibody-recognizing residues 188-211 of TMEM106B exhibit immunohistochemical reactivity with the TMEM106B C-terminal fragment

Accumulation of TMEM106B fibrils composed of cleaved C-terminal fragments (CTF) of transmembrane protein 106B (TMEM106B) has recently been observed in the brains of elderly subjects and individuals with neurodegenerative diseases. To date, one antibody recognizing the residues 239-250 has been found...

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Bibliographic Details
Main Authors: Ruoyi Ishikawa, Yu Yamazaki, Masahiro Nakamori, Tetsuya Takahashi, Hirofumi Maruyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Neuroscience
Subjects:
TMEM106B
C-terminal fragment
fibrils
new antibody
neurodegenerative disease
FTLD-MND
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1250547/full

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