Regulation of bone homeostasis by MERTK and TYRO3
The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated os...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-33938-x |
| _version_ | 1828090308356734976 |
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| author | Janik Engelmann Jennifer Zarrer Victoria Gensch Kristoffer Riecken Nikolaus Berenbrok The Vinh Luu Antonia Beitzen-Heineke Maria Elena Vargas-Delgado Klaus Pantel Carsten Bokemeyer Somasekhar Bhamidipati Ihab S. Darwish Esteban Masuda Tal Burstyn-Cohen Emily J. Alberto Sourav Ghosh Carla Rothlin Eric Hesse Hanna Taipaleenmäki Isabel Ben-Batalla Sonja Loges |
| author_facet | Janik Engelmann Jennifer Zarrer Victoria Gensch Kristoffer Riecken Nikolaus Berenbrok The Vinh Luu Antonia Beitzen-Heineke Maria Elena Vargas-Delgado Klaus Pantel Carsten Bokemeyer Somasekhar Bhamidipati Ihab S. Darwish Esteban Masuda Tal Burstyn-Cohen Emily J. Alberto Sourav Ghosh Carla Rothlin Eric Hesse Hanna Taipaleenmäki Isabel Ben-Batalla Sonja Loges |
| author_sort | Janik Engelmann |
| collection | DOAJ |
| description | The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated osteolytic bone disease |
| first_indexed | 2024-04-11T05:55:57Z |
| format | Article |
| id | doaj.art-ee00da2c9ae74841a30cb1a635750ba7 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T05:55:57Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ee00da2c9ae74841a30cb1a635750ba72022-12-22T04:41:55ZengNature PortfolioNature Communications2041-17232022-12-0113111510.1038/s41467-022-33938-xRegulation of bone homeostasis by MERTK and TYRO3Janik Engelmann0Jennifer Zarrer1Victoria Gensch2Kristoffer Riecken3Nikolaus Berenbrok4The Vinh Luu5Antonia Beitzen-Heineke6Maria Elena Vargas-Delgado7Klaus Pantel8Carsten Bokemeyer9Somasekhar Bhamidipati10Ihab S. Darwish11Esteban Masuda12Tal Burstyn-Cohen13Emily J. Alberto14Sourav Ghosh15Carla Rothlin16Eric Hesse17Hanna Taipaleenmäki18Isabel Ben-Batalla19Sonja Loges20Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfMolecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Stem Cell Transplantation, Research Department Cell and Gene Therapy, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfRigel Pharmaceuticals, Inc.Rigel Pharmaceuticals, Inc.Rigel Pharmaceuticals, Inc.Faculty of Dental Medicine, Institute for Dental Sciences, The Hebrew University of JerusalemDepartment of Immunobiology, Yale University School of MedicineDepartment of Pharmacology, Yale University School of MedicineDepartment of Immunobiology, Yale University School of MedicineInstitute of Musculoskeletal Medicine, University Hospital, LMU MunichMolecular Skeletal Biology Laboratory, Department of Trauma, Hand and Reconstructive Surgery, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfDepartment of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Comprehensive Cancer Center Hamburg, University Medical Center Hamburg-EppendorfThe TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation of bone metastasis including its associated osteolytic bone diseasehttps://doi.org/10.1038/s41467-022-33938-x |
| spellingShingle | Janik Engelmann Jennifer Zarrer Victoria Gensch Kristoffer Riecken Nikolaus Berenbrok The Vinh Luu Antonia Beitzen-Heineke Maria Elena Vargas-Delgado Klaus Pantel Carsten Bokemeyer Somasekhar Bhamidipati Ihab S. Darwish Esteban Masuda Tal Burstyn-Cohen Emily J. Alberto Sourav Ghosh Carla Rothlin Eric Hesse Hanna Taipaleenmäki Isabel Ben-Batalla Sonja Loges Regulation of bone homeostasis by MERTK and TYRO3 Nature Communications |
| title | Regulation of bone homeostasis by MERTK and TYRO3 |
| title_full | Regulation of bone homeostasis by MERTK and TYRO3 |
| title_fullStr | Regulation of bone homeostasis by MERTK and TYRO3 |
| title_full_unstemmed | Regulation of bone homeostasis by MERTK and TYRO3 |
| title_short | Regulation of bone homeostasis by MERTK and TYRO3 |
| title_sort | regulation of bone homeostasis by mertk and tyro3 |
| url | https://doi.org/10.1038/s41467-022-33938-x |
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