Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity

Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity

Abstract Background Colorectal cancer (CRC) is one of the most prevalent diagnosed malignancies and one of the leading causes of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) and its combination regimen are commonly used as primary chemotherapeutic agents for advanced CRC. Intestinal mucosi...

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Bibliographic Details
Main Authors: Jing Xia, Qian long Dai, Siyue He, Hui-jie Jia, Xian-Guo Liu, Hui Hua, Min Zhou, Xiaobo Wang
Format: Article
Language:English
Published: Springer 2023-07-01
Series:Discover Oncology
Subjects:
Artesunate
5-fluorouracil
Senescence
Intestinal damage
Inflammation
Colorectal cancer
Online Access:https://doi.org/10.1007/s12672-023-00747-7

Internet

https://doi.org/10.1007/s12672-023-00747-7

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