Vulvar Malignant Melanoma: A Narrative Review
Malignant melanoma is a fatal disease that affects all skin sites. Among these, vulvar melanoma (VM) is a rare gynecological condition that accounts for 5% of all vulvar neoplasms. VM primarily affects older Caucasian women and its relationship to sun exposure is undefined. Diagnosis is defined by b...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/21/5217 |
| _version_ | 1797468891920728064 |
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| author | Giovanni Falcicchio Lorenzo Vinci Ettore Cicinelli Vera Loizzi Francesca Arezzo Erica Silvestris Leonardo Resta Gabriella Serio Gerardo Cazzato Marialuigia Mastronardi Michele Mongelli Marco Marinaccio Gennaro Cormio |
| author_facet | Giovanni Falcicchio Lorenzo Vinci Ettore Cicinelli Vera Loizzi Francesca Arezzo Erica Silvestris Leonardo Resta Gabriella Serio Gerardo Cazzato Marialuigia Mastronardi Michele Mongelli Marco Marinaccio Gennaro Cormio |
| author_sort | Giovanni Falcicchio |
| collection | DOAJ |
| description | Malignant melanoma is a fatal disease that affects all skin sites. Among these, vulvar melanoma (VM) is a rare gynecological condition that accounts for 5% of all vulvar neoplasms. VM primarily affects older Caucasian women and its relationship to sun exposure is undefined. Diagnosis is defined by biopsy but many clinical, dermatoscopic, and confocal microscopic features can guide doctors. The molecular profile is characterized by the KIT mutation, revealed by all of the technologies that are used (classical sequencing, next-generation sequencing, and immunohistochemical staining). BRAF and NRAS mutations are also common in VM. All of these mutations are possible therapeutic targets. Today, surgery remains the first treatment choice for primary VM. The role of neoadjuvant and adjuvant therapy is scarce and the treatment of relapses is widely debated. |
| first_indexed | 2024-03-09T19:13:45Z |
| format | Article |
| id | doaj.art-ee02097463f94a9491e81b5da33d7fb0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T19:13:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ee02097463f94a9491e81b5da33d7fb02023-11-24T04:00:57ZengMDPI AGCancers2072-66942022-10-011421521710.3390/cancers14215217Vulvar Malignant Melanoma: A Narrative ReviewGiovanni Falcicchio0Lorenzo Vinci1Ettore Cicinelli2Vera Loizzi3Francesca Arezzo4Erica Silvestris5Leonardo Resta6Gabriella Serio7Gerardo Cazzato8Marialuigia Mastronardi9Michele Mongelli10Marco Marinaccio11Gennaro Cormio12Section of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Interdisciplinar Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalySection of Gynecology and Obstetrics, Department of Biomedical Sciences and Human Oncology (DIMO), University of Bari “Aldo Moro”, 70124 Bari, ItalyGynecologic Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyMalignant melanoma is a fatal disease that affects all skin sites. Among these, vulvar melanoma (VM) is a rare gynecological condition that accounts for 5% of all vulvar neoplasms. VM primarily affects older Caucasian women and its relationship to sun exposure is undefined. Diagnosis is defined by biopsy but many clinical, dermatoscopic, and confocal microscopic features can guide doctors. The molecular profile is characterized by the KIT mutation, revealed by all of the technologies that are used (classical sequencing, next-generation sequencing, and immunohistochemical staining). BRAF and NRAS mutations are also common in VM. All of these mutations are possible therapeutic targets. Today, surgery remains the first treatment choice for primary VM. The role of neoadjuvant and adjuvant therapy is scarce and the treatment of relapses is widely debated.https://www.mdpi.com/2072-6694/14/21/5217vulvar melanomarare gynecological cancertarget treatment |
| spellingShingle | Giovanni Falcicchio Lorenzo Vinci Ettore Cicinelli Vera Loizzi Francesca Arezzo Erica Silvestris Leonardo Resta Gabriella Serio Gerardo Cazzato Marialuigia Mastronardi Michele Mongelli Marco Marinaccio Gennaro Cormio Vulvar Malignant Melanoma: A Narrative Review Cancers vulvar melanoma rare gynecological cancer target treatment |
| title | Vulvar Malignant Melanoma: A Narrative Review |
| title_full | Vulvar Malignant Melanoma: A Narrative Review |
| title_fullStr | Vulvar Malignant Melanoma: A Narrative Review |
| title_full_unstemmed | Vulvar Malignant Melanoma: A Narrative Review |
| title_short | Vulvar Malignant Melanoma: A Narrative Review |
| title_sort | vulvar malignant melanoma a narrative review |
| topic | vulvar melanoma rare gynecological cancer target treatment |
| url | https://www.mdpi.com/2072-6694/14/21/5217 |
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