SAKK 21/12: a phase II trial of transdermal CR1447 in breast cancer patients

Objective: CR1447, a novel transdermal formulation of 4-hydroxytestosterone, has aromatase-inhibiting and androgen receptor (AR)-modulating properties (IC50 4.4 nM) with antitumor effects against AR-positive tumor cells in vitro. This trial investigated the efficacy and safety of CR1447 for patients...

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Main Authors: Marcus Vetter, Karin M Rothgiesser, Qiyu Li, Hanne Hawle, Wolfgang Schönfeld, Karin Ribi, Salome Riniker, Roger von Moos, Andreas Trojan, Elena Kralidis, Mathias Fehr, Andreas Müller, Beat Thürlimann
Format: Article
Language:English
Published: Bioscientifica 2023-01-01
Series:Endocrine Oncology
Subjects:
Online Access:https://eo.bioscientifica.com/view/journals/eo/2/1/EO-21-0009.xml