Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models

Nerolidol Mitigates Colonic Inflammation: An Experimental Study Using both In Vivo and In Vitro Models

Nerolidol (NED) is a naturally occurring sesquiterpene alcohol present in various plants with potent anti-inflammatory effects. In the current study, we investigated NED as a putative anti-inflammatory compound in an experimental model of colonic inflammation. C57BL/6J male black mice (C57BL/6J) wer...

Full description

Bibliographic Details
Main Authors:	Vishnu Raj, Balaji Venkataraman, Saeeda Almarzooqi, Sanjana Chandran, Shreesh K. Ojha, Samir Attoub, Thomas E. Adrian, Sandeep B. Subramanya
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Series:	Nutrients
Subjects:	nerolidol phytochemical inflammatory bowel disease bioactive compounds inflammatory molecular mechanisms colitis
Online Access:	https://www.mdpi.com/2072-6643/12/7/2032

Similar Items

Cis-Nerolidol Inhibits MAP Kinase and NF-κB Signaling Pathways and Prevents Epithelial Tight Junction Dysfunction in Colon Inflammation: In Vivo and In Vitro Studies
by: Vishnu Raj, et al.
Published: (2023-03-01)

Nerolidol: A Sesquiterpene Alcohol with Multi-Faceted Pharmacological and Biological Activities
by: Weng-Keong Chan, et al.
Published: (2016-04-01)

β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways
by: Saeeda Almarzooqi, et al.
Published: (2022-12-01)

Preparation and Characterization of Blank and Nerolidol-Loaded Chitosan–Alginate Nanoparticles
by: Rahaf M. Ahmad, et al.
Published: (2022-04-01)

The Effect of Nerolidol Renal Dysfunction following Ischemia–Reperfusion Injury in the Rat
by: Fayez T. Hammad, et al.
Published: (2023-01-01)

Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats
by: Seenipandi Arunachalam, et al.
Published: (2021-06-01)

Avaliação do potencial antioxidante in vitro do nerolidol
by: José Damasceno Nogueira Neto, et al.
Published: (2013-01-01)

Avaliação do potencial antioxidante in vitro do nerolidol
by: José Damasceno Nogueira Neto, et al.
Published: (2013-01-01)

Thymoquinone, a Dietary Bioactive Compound, Exerts Anti-Inflammatory Effects in Colitis by Stimulating Expression of the Colonic Epithelial PPAR-γ Transcription Factor
by: Balaji Venkataraman, et al.
Published: (2021-04-01)

Antifungal Properties of Nerolidol-Containing Liposomes in Association with Fluconazole
by: Camila Fonseca Bezerra, et al.
Published: (2020-08-01)

The effect of cyclodextrin complexation on the solubility and photostability of nerolidol as pure compound and as main constituent of cabreuva essential oil
by: Joyce Azzi, et al.
Published: (2017-05-01)

Mechanism of <i>cis</i>-Nerolidol-Induced Bladder Carcinoma Cell Death
by: Mateo Glumac, et al.
Published: (2023-02-01)

Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions
by: Alena Špičáková, et al.
Published: (2017-03-01)

Natural polysaccharides for ulcerative colitis: A general overview
by: Akshita Arora, et al.
Published: (2023-01-01)

Antischistosomal Activity of the Terpene Nerolidol
by: Marcos P.N. Silva, et al.
Published: (2014-03-01)

Effects of Selected Phytochemicals from Malaysian Plants on Cellular Models of Inflammation
by: Ahmad, Syahida
Published: (2006)

Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
by: Tripti Khare, et al.
Published: (2020-05-01)

New developments in ulcerative colitis: latest evidence on management, treatment, and maintenance
by: Kartikeya Tripathi, et al.
Published: (2019-04-01)

Ulcerative colitis: Al-gassim experience
by: Contractor Qais, et al.
Published: (2004-01-01)

Neutrophil Immunomodulatory Activity of Nerolidol, a Major Component of Essential Oils from <i>Populus balsamifera</i> Buds and Propolis
by: Igor A. Schepetkin, et al.
Published: (2022-12-01)

Probiotics in IBD: Combining in vitro and in vivo models for selecting strains with both anti-inflammatory potential as well as a capacity to restore the gut epithelial barrier
by: Mazen Zaylaa, et al.
Published: (2018-08-01)

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review
by: Lucas Fornari Laurindo, et al.
Published: (2023-02-01)

Is Infection Associated With Ulcerative Colitis Activity?
by: Ayoung Lee, et al.
Published: (2024-03-01)

Enteric infections complicating ulcerative colitis
by: Dejan Micic, et al.
Published: (2018-07-01)

Outcome of Cytomegalovirus Colitis in Inflammatory Bowel Disease with Different Regimes of Ganciclovir
by: Iftikhar Ahmed, et al.
Published: (2018-10-01)

Molecular Docking Identifies 1,8-Cineole (Eucalyptol) as A Novel PPARγ Agonist That Alleviates Colon Inflammation
by: Balaji Venkataraman, et al.
Published: (2023-03-01)

Childhood Inflammatory Bowel Disease in Libya: Epidemiological and Clinical Features
by: A Ahmaida, et al.
Published: (2009-01-01)

Investigating the Regulatory Mechanism of the Sesquiterpenol Nerolidol from a Plant on Juvenile Hormone-Related Genes in the Insect <i>Spodoptera exigua</i>
by: Hanyang Dai, et al.
Published: (2023-08-01)

Landscape of inflammatory bowel disease in Singapore
by: Daren Low, et al.
Published: (2022-07-01)

A Schistosoma Colitis Case Misdiagnosed as Ulcerative Colitis in a Non-Endemic Area: A Case Report
by: Çağatay Ak, et al.
Published: (2022-09-01)

Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
by: Holvoet T, et al.
Published: (2021-03-01)

Protective Effect of the Polyphenol Ligustroside on Colitis Induced with Dextran Sulfate Sodium in Mice
by: Ruonan Gao, et al.
Published: (2024-02-01)

Early Clinical Remission Is a Predictor of Long-Term Remission with the Use of Vedolizumab for Ulcerative Colitis
by: Keiichi Haga, et al.
Published: (2022-10-01)

CRAB score for prediction of colectomy within 2 years following admission for acute severe ulcerative colitis
by: Krishnadas Devadas, et al.
Published: (2023-01-01)

When disease extent is not always a key parameter: Management of refractory ulcerative proctitis
by: Georgios Michalopoulos, et al.
Published: (2022-01-01)

Ulcerative Colitis and Neopterin: Related?
by: Beşir Kesici, et al.
Published: (2019-04-01)

Relationship between Using Detergents and the Risk of Ulcerative Colitis in Mazandaran, Iran 2014-17
by: Zohreh Bari, et al.
Published: (2019-12-01)

C lostridioides difficile toxin is infrequently detected in inflammatory bowel disease and does not associate with clinical outcomes
by: Rachel Bernard, et al.
Published: (2022-08-01)

Curcumin-QingDai Combination as Treatment for Moderate-Severe Ulcerative Colitis
by: Shomron Ben-Horin, et al.
Published: (2022-09-01)

Severe de novo Ulcerative Colitis following Ixekizumab Therapy
by: Jobin Philipose, et al.
Published: (2018-10-01)