Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease
Context: Study of the prevalence of echocardiographic abnormalities and there relation to disease progression in chronic kidney disease (CKD). Aims: Study correlation of echocardiographic changes and CKD progression. Settings and Design: A prospective, cross-sectional, observational, analytical stud...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
| Subjects: | |
| Online Access: | http://www.jiaecho.org/article.asp?issn=2543-1463;year=2021;volume=5;issue=2;spage=127;epage=133;aulast=Garg |
| _version_ | 1818587675285782528 |
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| author | Praveen Garg Piyush Mathur Nitin Kansal Praveen Sharma Milind Shrivastava |
| author_facet | Praveen Garg Piyush Mathur Nitin Kansal Praveen Sharma Milind Shrivastava |
| author_sort | Praveen Garg |
| collection | DOAJ |
| description | Context: Study of the prevalence of echocardiographic abnormalities and there relation to disease progression in chronic kidney disease (CKD). Aims: Study correlation of echocardiographic changes and CKD progression. Settings and Design: A prospective, cross-sectional, observational, analytical study, where we performed complete echocardiographic evaluation of patients with CKD stage II–V. We compared various echocardiographic parameters to predict the progression of CKD. Subjects and Methods: Ninety CKD patients stage II–V presenting to our hospital from November 2016 to December 2017 were included in the study. A complete echocardiographic evaluation was done. Left ventricular hypertrophy (LVH), systolic and diastolic dysfunction using Doppler indices at mitral inflow, left atrial volume, speckle tracking, and global longitudinal strain (GLS) were studied. Results: Patients were age and sex matched in all the groups with a male preponderance. Forty-one patients (45.56%) were diabetic and 74 (82.22%) were hypertensive. The prevalence of hypertension increased from 66.67% to 89.29% as CKD stage progressed from stage II to stage V. There were significant echocardiographic abnormalities seen in CKD patients. The severity increased with worsening of the stages of CKD. LVH and early diastolic mitral inflow to annular velocity ratio progression was statistically significant when stage V was compared to stage II. Left atrial volume, mitral early diastolic to late diastolic velocity ratio, maximum tricuspid regurgitation (TRmax) velocity, and diastolic dysfunction prevalence were significantly raised in stage IV and stage V compared to stage II. Only GLS showed statistical significance between stage II to stage III, stage IV and stage V and thus predicting progression of CKD. Conclusions: LVH, dilated left atrium, abnormal GLS, TRmax, diastolic dysfunction, and related tissue Doppler imaging parameters correlate with worsening renal function. GLS was the only parameter showing significant difference between stage II and stage III. This can be used as a novel modality for detection of subclinical cardiac dysfunction in CKD. |
| first_indexed | 2024-12-16T09:12:38Z |
| format | Article |
| id | doaj.art-ee0629d3735d4039af6c7eabacdebdc2 |
| institution | Directory Open Access Journal |
| issn | 2543-1463 2543-1471 |
| language | English |
| last_indexed | 2024-12-16T09:12:38Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging |
| spelling | doaj.art-ee0629d3735d4039af6c7eabacdebdc22022-12-21T22:36:57ZengWolters Kluwer Medknow PublicationsJournal of the Indian Academy of Echocardiography & Cardiovascular Imaging2543-14632543-14712021-01-015212713310.4103/jiae.jiae_44_20Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney DiseasePraveen GargPiyush MathurNitin KansalPraveen SharmaMilind ShrivastavaContext: Study of the prevalence of echocardiographic abnormalities and there relation to disease progression in chronic kidney disease (CKD). Aims: Study correlation of echocardiographic changes and CKD progression. Settings and Design: A prospective, cross-sectional, observational, analytical study, where we performed complete echocardiographic evaluation of patients with CKD stage II–V. We compared various echocardiographic parameters to predict the progression of CKD. Subjects and Methods: Ninety CKD patients stage II–V presenting to our hospital from November 2016 to December 2017 were included in the study. A complete echocardiographic evaluation was done. Left ventricular hypertrophy (LVH), systolic and diastolic dysfunction using Doppler indices at mitral inflow, left atrial volume, speckle tracking, and global longitudinal strain (GLS) were studied. Results: Patients were age and sex matched in all the groups with a male preponderance. Forty-one patients (45.56%) were diabetic and 74 (82.22%) were hypertensive. The prevalence of hypertension increased from 66.67% to 89.29% as CKD stage progressed from stage II to stage V. There were significant echocardiographic abnormalities seen in CKD patients. The severity increased with worsening of the stages of CKD. LVH and early diastolic mitral inflow to annular velocity ratio progression was statistically significant when stage V was compared to stage II. Left atrial volume, mitral early diastolic to late diastolic velocity ratio, maximum tricuspid regurgitation (TRmax) velocity, and diastolic dysfunction prevalence were significantly raised in stage IV and stage V compared to stage II. Only GLS showed statistical significance between stage II to stage III, stage IV and stage V and thus predicting progression of CKD. Conclusions: LVH, dilated left atrium, abnormal GLS, TRmax, diastolic dysfunction, and related tissue Doppler imaging parameters correlate with worsening renal function. GLS was the only parameter showing significant difference between stage II and stage III. This can be used as a novel modality for detection of subclinical cardiac dysfunction in CKD.http://www.jiaecho.org/article.asp?issn=2543-1463;year=2021;volume=5;issue=2;spage=127;epage=133;aulast=Gargchronic kidney diseasediastolic dysfunctionechocardiographyglobal logitudinal strain |
| spellingShingle | Praveen Garg Piyush Mathur Nitin Kansal Praveen Sharma Milind Shrivastava Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease Journal of the Indian Academy of Echocardiography & Cardiovascular Imaging chronic kidney disease diastolic dysfunction echocardiography global logitudinal strain |
| title | Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease |
| title_full | Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease |
| title_fullStr | Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease |
| title_full_unstemmed | Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease |
| title_short | Study of the Prevalence of Echocardiographic Abnormalities and Their Relation to Disease Progression in Chronic Kidney Disease |
| title_sort | study of the prevalence of echocardiographic abnormalities and their relation to disease progression in chronic kidney disease |
| topic | chronic kidney disease diastolic dysfunction echocardiography global logitudinal strain |
| url | http://www.jiaecho.org/article.asp?issn=2543-1463;year=2021;volume=5;issue=2;spage=127;epage=133;aulast=Garg |
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