C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls
There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02230/full |
| _version_ | 1819237626932101120 |
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| author | Isabella Jacomb Clive Stanton Clive Stanton Clive Stanton Rohini Vasudevan Hugh Powell Maryanne O'Donnell Maryanne O'Donnell Maryanne O'Donnell Rhoshel Lenroot Rhoshel Lenroot Rhoshel Lenroot Jason Bruggemann Jason Bruggemann Ryan Balzan Ryan Balzan Cherrie Galletly Cherrie Galletly Dennis Liu Dennis Liu Cynthia S. Weickert Cynthia S. Weickert Cynthia S. Weickert Thomas W. Weickert Thomas W. Weickert |
| author_facet | Isabella Jacomb Clive Stanton Clive Stanton Clive Stanton Rohini Vasudevan Hugh Powell Maryanne O'Donnell Maryanne O'Donnell Maryanne O'Donnell Rhoshel Lenroot Rhoshel Lenroot Rhoshel Lenroot Jason Bruggemann Jason Bruggemann Ryan Balzan Ryan Balzan Cherrie Galletly Cherrie Galletly Dennis Liu Dennis Liu Cynthia S. Weickert Cynthia S. Weickert Cynthia S. Weickert Thomas W. Weickert Thomas W. Weickert |
| author_sort | Isabella Jacomb |
| collection | DOAJ |
| description | There is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent samples, we assessed the peripheral inflammation marker C-reactive protein (CRP) to determine the extent to which: (1) CRP was elevated and stable across admissions for acute psychosis, (2) cognition, daily function and symptom severity are characteristic of chronically ill patients with schizophrenia displaying elevated CRP, and (3) CRP levels predict cortical thickness. Study 1 assessed peripheral CRP (primary outcome) and other blood measures in 174/280 people with acute psychosis while Study 2 assessed peripheral CRP, cognition and cortical thickness (primary outcomes), symptoms, and daily function in 85/97 chronically ill patients with schizophrenia and 71/87 healthy controls. In acute psychosis, CRP and neutrophil-to-lymphocyte ratio were significantly elevated relative to a normal cutoff (with 59.8% of patients having elevated CRP) which remained elevated across admissions. CRP was significantly elevated in 43% of chronically ill patients with schizophrenia compared to 20% in controls. Elevated CRP patients displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions. This work supports the role of inflammation in psychotic illnesses and suggests that use of peripheral markers (e.g., CRP) in conjunction with diagnosis could be used to identify patients with more cortical neuropathology and cognitive deficits. |
| first_indexed | 2024-12-23T13:23:20Z |
| format | Article |
| id | doaj.art-ee0636d91f5249b5821c41468720d494 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T13:23:20Z |
| publishDate | 2018-10-01 |
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| series | Frontiers in Immunology |
| spelling | doaj.art-ee0636d91f5249b5821c41468720d4942022-12-21T17:45:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-10-01910.3389/fimmu.2018.02230409870C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy ControlsIsabella Jacomb0Clive Stanton1Clive Stanton2Clive Stanton3Rohini Vasudevan4Hugh Powell5Maryanne O'Donnell6Maryanne O'Donnell7Maryanne O'Donnell8Rhoshel Lenroot9Rhoshel Lenroot10Rhoshel Lenroot11Jason Bruggemann12Jason Bruggemann13Ryan Balzan14Ryan Balzan15Cherrie Galletly16Cherrie Galletly17Dennis Liu18Dennis Liu19Cynthia S. Weickert20Cynthia S. Weickert21Cynthia S. Weickert22Thomas W. Weickert23Thomas W. Weickert24Schizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaPrince of Wales Hospital, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaPrince of Wales Hospital, Randwick, NSW, AustraliaPrince of Wales Hospital, Randwick, NSW, AustraliaSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaPrince of Wales Hospital, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaPrince of Wales Hospital, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, AustraliaCollege of Education, Psychology and Social Work, Flinders University, Adelaide, SA, AustraliaDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, AustraliaNorthern Adelaide Local Health Network, Adelaide, SA, AustraliaDiscipline of Psychiatry, University of Adelaide, Adelaide, SA, AustraliaNorthern Adelaide Local Health Network, Adelaide, SA, AustraliaSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaDepartment of Neuroscience and Physiology, Upstate Medical University, Syracuse, NY, United StatesSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, AustraliaSchool of Psychiatry, University of New South Wales, Randwick, NSW, AustraliaThere is increasing evidence for the role of inflammation in schizophrenia, yet the stability of increased peripheral inflammation in acute psychosis and the degree to which peripheral inflammation relates to cortical thickness, a measure of the degree of neuropathology, are unknown. In independent samples, we assessed the peripheral inflammation marker C-reactive protein (CRP) to determine the extent to which: (1) CRP was elevated and stable across admissions for acute psychosis, (2) cognition, daily function and symptom severity are characteristic of chronically ill patients with schizophrenia displaying elevated CRP, and (3) CRP levels predict cortical thickness. Study 1 assessed peripheral CRP (primary outcome) and other blood measures in 174/280 people with acute psychosis while Study 2 assessed peripheral CRP, cognition and cortical thickness (primary outcomes), symptoms, and daily function in 85/97 chronically ill patients with schizophrenia and 71/87 healthy controls. In acute psychosis, CRP and neutrophil-to-lymphocyte ratio were significantly elevated relative to a normal cutoff (with 59.8% of patients having elevated CRP) which remained elevated across admissions. CRP was significantly elevated in 43% of chronically ill patients with schizophrenia compared to 20% in controls. Elevated CRP patients displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions. This work supports the role of inflammation in psychotic illnesses and suggests that use of peripheral markers (e.g., CRP) in conjunction with diagnosis could be used to identify patients with more cortical neuropathology and cognitive deficits.https://www.frontiersin.org/article/10.3389/fimmu.2018.02230/fullschizophreniaacute psychosisc-reactive proteincortical thicknessinflammationworking memory |
| spellingShingle | Isabella Jacomb Clive Stanton Clive Stanton Clive Stanton Rohini Vasudevan Hugh Powell Maryanne O'Donnell Maryanne O'Donnell Maryanne O'Donnell Rhoshel Lenroot Rhoshel Lenroot Rhoshel Lenroot Jason Bruggemann Jason Bruggemann Ryan Balzan Ryan Balzan Cherrie Galletly Cherrie Galletly Dennis Liu Dennis Liu Cynthia S. Weickert Cynthia S. Weickert Cynthia S. Weickert Thomas W. Weickert Thomas W. Weickert C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls Frontiers in Immunology schizophrenia acute psychosis c-reactive protein cortical thickness inflammation working memory |
| title | C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls |
| title_full | C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls |
| title_fullStr | C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls |
| title_full_unstemmed | C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls |
| title_short | C-Reactive Protein: Higher During Acute Psychotic Episodes and Related to Cortical Thickness in Schizophrenia and Healthy Controls |
| title_sort | c reactive protein higher during acute psychotic episodes and related to cortical thickness in schizophrenia and healthy controls |
| topic | schizophrenia acute psychosis c-reactive protein cortical thickness inflammation working memory |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02230/full |
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