Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

Pravastatin Attenuates Acute Radiation-Induced Enteropathy and Improves Epithelial Cell Function

Background and Aim: Radiation-induced enteropathy is frequently observed after radiation therapy for abdominal and pelvic cancer or occurs secondary to accidental radiation exposure. The acute effects of irradiation on the intestine might be attributed to inhibition of mitosis in the crypts, as the...

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Main Authors: Hyosun Jang, Janet Lee, Sunhoo Park, Hyunwook Myung, Jihoon Kang, Kyuchang Kim, Hyewon Kim, Won-Suk Jang, Sun-Joo Lee, Sehwan Shim, Jae K. Myung
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
pravastatin
radiation-induced enteropathy
intestinal epithelial cells
oxidative stress
irradiation
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01215/full

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