Estudos de relações estrutura-atividade quantitativas (QSAR) de bis-benzamidinas com atividade antifúngica Quantitative structure-activity relationships (QSAR) studies of bisbenzamidines with antifungal activity

Estudos de relações estrutura-atividade quantitativas (QSAR) de bis-benzamidinas com atividade antifúngica Quantitative structure-activity relationships (QSAR) studies of bisbenzamidines with antifungal activity

<abstract language="eng">This paper describes 2D-QSAR and 3D-QSAR studies against Candida albicans and Cryptococcus neofarmans for a set of 20 bisbenzamidines. In the studies of 2D-QSAR with C. albicans it was obtained a correlation between log MIC-1 and lipolo component-Z (r² = 0.68...

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Bibliographic Details
Main Authors: Vera L. de Almeida, Júlio César Dias Lopes, Sheila Rodrigues Oliveira, Claudio L. Donnici, Carlos A. Montanari
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2010-01-01
Series:Química Nova
Subjects:
QSAR
bis-benzamidines
antifungal activity
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000700011

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