14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease

14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease

Alzheimer’s disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal proteins, such as tau and beta-amyloid, in the brain is a hallmark of AD pathology. 14-3-3 proteins have been implicated in AD pathology in several way...

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Bibliographic Details
Main Authors: Gholamareza Abdi, Mukul Jain, Nil Patil, Bindiya Upadhyay, Nigam Vyas, Manish Dwivedi, Radhey Shyam Kaushal
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
14-3-3 protein
Alzheimer’s disease
tau protein
mutations
phosphorylation binding grove
protein-protein interaction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1286536/full

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