Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research
Tear fluid forms the outermost layer of the ocular surface and its characteristics and composition have been connected to various ocular surface diseases. As tear proteomics enables the non-invasive investigation of protein levels in the tear fluid, it has become an increasingly popular approach in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8136 |
| _version_ | 1797432942541144064 |
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| author | Janika Nättinen Ulla Aapola Praveena Nukareddy Hannu Uusitalo |
| author_facet | Janika Nättinen Ulla Aapola Praveena Nukareddy Hannu Uusitalo |
| author_sort | Janika Nättinen |
| collection | DOAJ |
| description | Tear fluid forms the outermost layer of the ocular surface and its characteristics and composition have been connected to various ocular surface diseases. As tear proteomics enables the non-invasive investigation of protein levels in the tear fluid, it has become an increasingly popular approach in ocular surface and systemic disease studies. Glaucoma, which is a set of multifactorial diseases affecting mainly the optic nerve and retinal ganglion cells, has also been studied using tear proteomics. In this condition, the complete set of pathophysiological changes occurring in the eye is not yet fully understood, and biomarkers for early diagnosis and accurate treatment selection are needed. More in-depth analyses of glaucoma tear proteomics have started to emerge only more recently with the implementation of LC-MS/MS and other modern technologies. The aim of this review was to examine the published data of the tear protein changes occurring during glaucoma, its topical treatment, and surgical interventions. |
| first_indexed | 2024-03-09T10:09:00Z |
| format | Article |
| id | doaj.art-ee0fcf0b33d14e53b86602929f36e172 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:09:00Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-ee0fcf0b33d14e53b86602929f36e1722023-12-01T22:56:54ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315813610.3390/ijms23158136Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma ResearchJanika Nättinen0Ulla Aapola1Praveena Nukareddy2Hannu Uusitalo3Eye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandEye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandEye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandEye and Vision Research, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, FinlandTear fluid forms the outermost layer of the ocular surface and its characteristics and composition have been connected to various ocular surface diseases. As tear proteomics enables the non-invasive investigation of protein levels in the tear fluid, it has become an increasingly popular approach in ocular surface and systemic disease studies. Glaucoma, which is a set of multifactorial diseases affecting mainly the optic nerve and retinal ganglion cells, has also been studied using tear proteomics. In this condition, the complete set of pathophysiological changes occurring in the eye is not yet fully understood, and biomarkers for early diagnosis and accurate treatment selection are needed. More in-depth analyses of glaucoma tear proteomics have started to emerge only more recently with the implementation of LC-MS/MS and other modern technologies. The aim of this review was to examine the published data of the tear protein changes occurring during glaucoma, its topical treatment, and surgical interventions.https://www.mdpi.com/1422-0067/23/15/8136glaucomaproteomicstear fluid |
| spellingShingle | Janika Nättinen Ulla Aapola Praveena Nukareddy Hannu Uusitalo Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research International Journal of Molecular Sciences glaucoma proteomics tear fluid |
| title | Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research |
| title_full | Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research |
| title_fullStr | Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research |
| title_full_unstemmed | Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research |
| title_short | Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research |
| title_sort | clinical tear fluid proteomics a novel tool in glaucoma research |
| topic | glaucoma proteomics tear fluid |
| url | https://www.mdpi.com/1422-0067/23/15/8136 |
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