The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation

The global downregulation of protein synthesis observed during hepatogenic maturation is associated with a decrease in TOP mRNA translation

Summary: Translational regulation is of paramount importance for proteome remodeling during stem cell differentiation at both the global and the transcript-specific levels. In this study, we characterized translational remodeling during hepatogenic differentiation of induced pluripotent stem cells (...

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Bibliographic Details
Main Authors: Marino Caruso, Sébastien Meurant, Damien Detraux, Amandine Mathieu, Manon Gilson, Marc Dieu, Antoine Fattaccioli, Catherine Demazy, Mustapha Najimi, Etienne Sokal, Thierry Arnould, Catherine Verfaillie, Denis L.J. Lafontaine, Patricia Renard
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Stem Cell Reports
Subjects:
stem cells
hepatocyte differentiation
translational regulation
TOP mRNA
iPSC
polysome profiling
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671122005537

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http://www.sciencedirect.com/science/article/pii/S2213671122005537

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