The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience
This paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding. This paper commences by exploring the cerebrospinal fluid (CSF)—its localization, production, and pivotal role within the central ner...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/7/1005 |
| _version_ | 1797590068048691200 |
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| author | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia Petre Costin Vicentiu Mircea Saceleanu |
| author_facet | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia Petre Costin Vicentiu Mircea Saceleanu |
| author_sort | Alexandru Vlad Ciurea |
| collection | DOAJ |
| description | This paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding. This paper commences by exploring the cerebrospinal fluid (CSF)—its localization, production, and pivotal role within the central nervous system, acting as a cushion and vehicle for nutrient distribution and waste elimination. We then transition into an in-depth study of the morphophysiological aspects of the glymphatic system, a recent discovery revolutionizing the perception of waste clearance from the brain, highlighting its lymphatic-like characteristics and remarkable operations. This paper subsequently emphasizes the glymphatic system’s potential implications in Alzheimer’s disease (AD), discussing the connection between inefficient glymphatic clearance and AD pathogenesis. This review also elucidates the intriguing interplay between the glymphatic system and the circadian rhythm, illustrating the optimal functioning of glymphatic clearance during sleep. Lastly, we underscore the hitherto underappreciated involvement of the glymphatic system in the tumoral microenvironment, potentially impacting tumor growth and progression. This comprehensive paper accentuates the glymphatic system’s pivotal role in multiple domains, fostering an understanding of the brain’s waste clearance mechanisms and offering avenues for further research into neuropathological conditions. |
| first_indexed | 2024-03-11T01:15:05Z |
| format | Article |
| id | doaj.art-ee14fce5fcdf43eeabf42aaf67bc9d05 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T01:15:05Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-ee14fce5fcdf43eeabf42aaf67bc9d052023-11-18T18:34:00ZengMDPI AGBrain Sciences2076-34252023-06-01137100510.3390/brainsci13071005The Brain’s Glymphatic System: Drawing New Perspectives in NeuroscienceAlexandru Vlad Ciurea0Aurel George Mohan1Razvan-Adrian Covache-Busuioc2Horia Petre Costin3Vicentiu Mircea Saceleanu4Neurosurgery Department, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Neurosurgery, Bihor County Emergency Clinical Hospital, 410167 Oradea, RomaniaNeurosurgery Department, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeurosurgery Department, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaNeurosurgery Department, Sibiu County Emergency Hospital, 550245 Sibiu, RomaniaThis paper delves into the intricate structure and functionality of the brain’s glymphatic system, bringing forth new dimensions in its neuroscientific understanding. This paper commences by exploring the cerebrospinal fluid (CSF)—its localization, production, and pivotal role within the central nervous system, acting as a cushion and vehicle for nutrient distribution and waste elimination. We then transition into an in-depth study of the morphophysiological aspects of the glymphatic system, a recent discovery revolutionizing the perception of waste clearance from the brain, highlighting its lymphatic-like characteristics and remarkable operations. This paper subsequently emphasizes the glymphatic system’s potential implications in Alzheimer’s disease (AD), discussing the connection between inefficient glymphatic clearance and AD pathogenesis. This review also elucidates the intriguing interplay between the glymphatic system and the circadian rhythm, illustrating the optimal functioning of glymphatic clearance during sleep. Lastly, we underscore the hitherto underappreciated involvement of the glymphatic system in the tumoral microenvironment, potentially impacting tumor growth and progression. This comprehensive paper accentuates the glymphatic system’s pivotal role in multiple domains, fostering an understanding of the brain’s waste clearance mechanisms and offering avenues for further research into neuropathological conditions.https://www.mdpi.com/2076-3425/13/7/1005glymphatic systembrain physiologyastrocytesAQP4Alzheimer’s diseasecircadian rhythm |
| spellingShingle | Alexandru Vlad Ciurea Aurel George Mohan Razvan-Adrian Covache-Busuioc Horia Petre Costin Vicentiu Mircea Saceleanu The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience Brain Sciences glymphatic system brain physiology astrocytes AQP4 Alzheimer’s disease circadian rhythm |
| title | The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience |
| title_full | The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience |
| title_fullStr | The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience |
| title_full_unstemmed | The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience |
| title_short | The Brain’s Glymphatic System: Drawing New Perspectives in Neuroscience |
| title_sort | brain s glymphatic system drawing new perspectives in neuroscience |
| topic | glymphatic system brain physiology astrocytes AQP4 Alzheimer’s disease circadian rhythm |
| url | https://www.mdpi.com/2076-3425/13/7/1005 |
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