The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study
(1) Background: Pregnancy-induced hypertension (PIH) is associated with obvious microbiota dysbiosis in the third trimester of pregnancy. However, the mechanisms behind these changes remain unknown. Therefore, this study aimed to explore the relationship between the gut microbiome in early pregnancy...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/21/4582 |
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| author | Huijun Lin Junru Chen Shujuan Ma Rongjing An Xingli Li Hongzhuan Tan |
| author_facet | Huijun Lin Junru Chen Shujuan Ma Rongjing An Xingli Li Hongzhuan Tan |
| author_sort | Huijun Lin |
| collection | DOAJ |
| description | (1) Background: Pregnancy-induced hypertension (PIH) is associated with obvious microbiota dysbiosis in the third trimester of pregnancy. However, the mechanisms behind these changes remain unknown. Therefore, this study aimed to explore the relationship between the gut microbiome in early pregnancy and PIH occurrence. (2) Methods: A nested case–control study design was used based on the follow-up cohort. Thirty-five PIH patients and thirty-five matched healthy pregnant women were selected as controls. The gut microbiome profiles were assessed in the first trimester using metagenomic sequencing. (3) Results: Diversity analyses showed that microbiota diversity was altered in early pregnancy. At the species level, eight bacterial species were enriched in healthy controls: <i>Alistipes putredinis</i>, <i>Bacteroides vulgatus</i>, <i>Ruminococcus torques</i>, <i>Oscillibacter unclassified</i>, <i>Akkermansia muciniphila</i>, <i>Clostridium citroniae</i>, <i>Parasutterella excrementihominis</i> and <i>Burkholderiales bacterium_1_1_47</i>. Conversely, <i>Eubacterium rectale</i>, and <i>Ruminococcus bromii</i> were enriched in PIH patients. The results of functional analysis showed that the changes in these different microorganisms may affect the blood pressure of pregnant women by affecting the metabolism of vitamin K<sub>2</sub>, sphingolipid, lipid acid and glycine. (4) Conclusion: Microbiota dysbiosis in PIH patients begins in the first trimester of pregnancy, and this may be associated with the occurrence of PIH. Bacterial pathway analyses suggest that the gut microbiome might lead to the development of PIH through the alterations of function modules. |
| first_indexed | 2024-03-09T18:46:32Z |
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| language | English |
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| series | Nutrients |
| spelling | doaj.art-ee16b47e9d754539a748fe9250917f552023-11-24T06:13:52ZengMDPI AGNutrients2072-66432022-11-011421458210.3390/nu14214582The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control StudyHuijun Lin0Junru Chen1Shujuan Ma2Rongjing An3Xingli Li4Hongzhuan Tan5Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410000, ChinaClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410000, ChinaClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410000, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410000, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410000, ChinaHunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410000, China(1) Background: Pregnancy-induced hypertension (PIH) is associated with obvious microbiota dysbiosis in the third trimester of pregnancy. However, the mechanisms behind these changes remain unknown. Therefore, this study aimed to explore the relationship between the gut microbiome in early pregnancy and PIH occurrence. (2) Methods: A nested case–control study design was used based on the follow-up cohort. Thirty-five PIH patients and thirty-five matched healthy pregnant women were selected as controls. The gut microbiome profiles were assessed in the first trimester using metagenomic sequencing. (3) Results: Diversity analyses showed that microbiota diversity was altered in early pregnancy. At the species level, eight bacterial species were enriched in healthy controls: <i>Alistipes putredinis</i>, <i>Bacteroides vulgatus</i>, <i>Ruminococcus torques</i>, <i>Oscillibacter unclassified</i>, <i>Akkermansia muciniphila</i>, <i>Clostridium citroniae</i>, <i>Parasutterella excrementihominis</i> and <i>Burkholderiales bacterium_1_1_47</i>. Conversely, <i>Eubacterium rectale</i>, and <i>Ruminococcus bromii</i> were enriched in PIH patients. The results of functional analysis showed that the changes in these different microorganisms may affect the blood pressure of pregnant women by affecting the metabolism of vitamin K<sub>2</sub>, sphingolipid, lipid acid and glycine. (4) Conclusion: Microbiota dysbiosis in PIH patients begins in the first trimester of pregnancy, and this may be associated with the occurrence of PIH. Bacterial pathway analyses suggest that the gut microbiome might lead to the development of PIH through the alterations of function modules.https://www.mdpi.com/2072-6643/14/21/4582pregnancy-induced hypertensiongut microbiomemetagenomic sequencingnested case–control study |
| spellingShingle | Huijun Lin Junru Chen Shujuan Ma Rongjing An Xingli Li Hongzhuan Tan The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study Nutrients pregnancy-induced hypertension gut microbiome metagenomic sequencing nested case–control study |
| title | The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study |
| title_full | The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study |
| title_fullStr | The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study |
| title_full_unstemmed | The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study |
| title_short | The Association between Gut Microbiome and Pregnancy-Induced Hypertension: A Nested Case–Control Study |
| title_sort | association between gut microbiome and pregnancy induced hypertension a nested case control study |
| topic | pregnancy-induced hypertension gut microbiome metagenomic sequencing nested case–control study |
| url | https://www.mdpi.com/2072-6643/14/21/4582 |
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