Design of Novel GPR6 Inverse Agonists Using a Fragment Replacement Scaffold Hopping Approach

Design of Novel GPR6 Inverse Agonists Using a Fragment Replacement Scaffold Hopping Approach

The orphan G protein coupled receptor 6 (GPR6) is a cannabinoid-related Class A GPCR. It is highly expressed in the central nervous system and exhibits high constitutive activation of adenylyl cyclase. Several research groups have demonstrated that GPR6 represents a possible target for the treatment...

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Bibliographic Details
Main Authors: Israa Isawi, Paula Morales, Dow Hurst, Nadine Jagerovic, Patricia Reggio
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Proceedings
Subjects:
GPR6
Scaffold Hopping
Parkinson’s Disease
Online Access:https://www.mdpi.com/2504-3900/22/1/29

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