NF-κB/mTOR/MYC Axis Drives PRMT5 Protein Induction After T Cell Activation via Transcriptional and Non-transcriptional Mechanisms

NF-κB/mTOR/MYC Axis Drives PRMT5 Protein Induction After T Cell Activation via Transcriptional and Non-transcriptional Mechanisms

Multiple sclerosis is an autoimmune disease of the central nervous system (CNS) mediated by CD4+ T cells and modeled via experimental autoimmune encephalomyelitis (EAE). Inhibition of PRMT5, the major Type II arginine methyltransferase, suppresses pathogenic T cell responses and EAE. PRMT5 is transi...

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Bibliographic Details
Main Authors: Lindsay M. Webb, Janiret Narvaez Miranda, Stephanie A. Amici, Shouvonik Sengupta, Gregory Nagy, Mireia Guerau-de-Arellano
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
PRMT5
T cell
signaling
multiple sclerosis
naive
memory
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00524/full

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