APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM<sub>2.5</sub> Polluted Cities

APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM<sub>2.5</sub> Polluted Cities

This Review emphasizes the impact of APOE4—the most significant genetic risk factor for Alzheimer’s disease (AD)—on peripheral and neural effects starting in childhood. We discuss major mechanistic players associated with the APOE alleles’ effects in humans to understand their impact from conception...

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Bibliographic Details
Main Authors: Lilian Calderón-Garcidueñas, Jacqueline Hernández-Luna, Mario Aiello-Mora, Rafael Brito-Aguilar, Pablo A. Evelson, Rodolfo Villarreal-Ríos, Ricardo Torres-Jardón, Alberto Ayala, Partha S. Mukherjee
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomolecules
Subjects:
air pollution
children
Alzheimer
APOE4
early biomarkers
amyloid beta
Online Access:https://www.mdpi.com/2218-273X/13/6/927

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