| Summary: | Intracellular calcium (Ca<sup>2+</sup>) concentration ([Ca<sup>2+</sup>]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca<sup>2+</sup>]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca<sup>2+</sup> signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca<sup>2+</sup> signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca<sup>2+</sup> signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.
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