Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer
Intracellular calcium (Ca<sup>2+</sup>) concentration ([Ca<sup>2+</sup>]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the...
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MDPI AG
2022-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/19/3003 |
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| author | Jiahui Lei Fengying Deng Hongmei Ding Mengyu Fu Ting Xu Bingyu Ji Lin Feng Min Li Junlan Qiu Qinqin Gao |
| author_facet | Jiahui Lei Fengying Deng Hongmei Ding Mengyu Fu Ting Xu Bingyu Ji Lin Feng Min Li Junlan Qiu Qinqin Gao |
| author_sort | Jiahui Lei |
| collection | DOAJ |
| description | Intracellular calcium (Ca<sup>2+</sup>) concentration ([Ca<sup>2+</sup>]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca<sup>2+</sup>]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca<sup>2+</sup> signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca<sup>2+</sup> signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca<sup>2+</sup> signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery. |
| first_indexed | 2024-03-09T21:54:18Z |
| format | Article |
| id | doaj.art-ee192a4d74b949fb963f33274a67562c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T21:54:18Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ee192a4d74b949fb963f33274a67562c2023-11-23T20:00:56ZengMDPI AGCells2073-44092022-09-011119300310.3390/cells11193003Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical CancerJiahui Lei0Fengying Deng1Hongmei Ding2Mengyu Fu3Ting Xu4Bingyu Ji5Lin Feng6Min Li7Junlan Qiu8Qinqin Gao9Institute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Oncology and Hematology, Suzhou Science and Technology Town Hospital, Suzhou 215153, ChinaDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaDepartment of Oncology and Hematology, Suzhou Science and Technology Town Hospital, Suzhou 215153, ChinaInstitute for Fetology, The First Affiliated Hospital of Soochow University, Suzhou 215006, ChinaIntracellular calcium (Ca<sup>2+</sup>) concentration ([Ca<sup>2+</sup>]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca<sup>2+</sup>]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca<sup>2+</sup> signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca<sup>2+</sup> signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca<sup>2+</sup> signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.https://www.mdpi.com/2073-4409/11/19/3003cervical cancerCa<sup>2+</sup> signalsoccurrencedevelopmentprognosis |
| spellingShingle | Jiahui Lei Fengying Deng Hongmei Ding Mengyu Fu Ting Xu Bingyu Ji Lin Feng Min Li Junlan Qiu Qinqin Gao Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer Cells cervical cancer Ca<sup>2+</sup> signals occurrence development prognosis |
| title | Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer |
| title_full | Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer |
| title_fullStr | Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer |
| title_full_unstemmed | Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer |
| title_short | Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer |
| title_sort | recent developments on the roles of calcium signals and potential therapy targets in cervical cancer |
| topic | cervical cancer Ca<sup>2+</sup> signals occurrence development prognosis |
| url | https://www.mdpi.com/2073-4409/11/19/3003 |
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