Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review
Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions,...
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Format: | Article |
Language: | English |
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BMC
2012-01-01
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Series: | Biological Research |
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Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008 |
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author | Fernando E Figueroa Flavio Carrión Sandra Villanueva Maroun Khoury |
author_facet | Fernando E Figueroa Flavio Carrión Sandra Villanueva Maroun Khoury |
author_sort | Fernando E Figueroa |
collection | DOAJ |
description | Mesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohn's disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future advances from stem cell science can be expected to pinpoint significant MSC subpopulations and/or stem cell markers for improved regenerative or immunoregulatory properties. |
first_indexed | 2024-04-13T12:42:19Z |
format | Article |
id | doaj.art-ee19ab4cba744d9980e4a8270fa58dcc |
institution | Directory Open Access Journal |
issn | 0716-9760 0717-6287 |
language | English |
last_indexed | 2024-04-13T12:42:19Z |
publishDate | 2012-01-01 |
publisher | BMC |
record_format | Article |
series | Biological Research |
spelling | doaj.art-ee19ab4cba744d9980e4a8270fa58dcc2022-12-22T02:46:29ZengBMCBiological Research0716-97600717-62872012-01-01453269277Mesenchymal Stem Cell treatment for autoimmune diseases: a critical reviewFernando E FigueroaFlavio CarriónSandra VillanuevaMaroun KhouryMesenchymal stem cells (MSCs) are now known to display not only stem cell multipotency, but also robust antiinflammatory and regenerative properties. After widespread in-vitro and in-vivo preclinical testing, autologous and allogeneic MSCs have been applied in a range of immune mediated conditions, including graft versus host disease, Crohn's disease, multiple sclerosis, refractory systemic lupus erythematosus and systemic sclerosis. Current data suggests that MSCs may not only replace diseased tissues, but also exert several trophic, regenerative and antiinflammatory effects. While the clinical outcome in case reports and phase I-II trials seems occasionally striking, these limited results point to the need to perform controlled multicenter trials. Future advances from stem cell science can be expected to pinpoint significant MSC subpopulations and/or stem cell markers for improved regenerative or immunoregulatory properties.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008Mesenchymal stem cellsautoimmune diseasescellular therapy |
spellingShingle | Fernando E Figueroa Flavio Carrión Sandra Villanueva Maroun Khoury Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review Biological Research Mesenchymal stem cells autoimmune diseases cellular therapy |
title | Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review |
title_full | Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review |
title_fullStr | Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review |
title_full_unstemmed | Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review |
title_short | Mesenchymal Stem Cell treatment for autoimmune diseases: a critical review |
title_sort | mesenchymal stem cell treatment for autoimmune diseases a critical review |
topic | Mesenchymal stem cells autoimmune diseases cellular therapy |
url | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300008 |
work_keys_str_mv | AT fernandoefigueroa mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT flaviocarrion mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT sandravillanueva mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview AT marounkhoury mesenchymalstemcelltreatmentforautoimmunediseasesacriticalreview |