High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era

High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era

Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patient...

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Bibliographic Details
Main Authors: Francesca De Felice, Ilaria Clementi, Valeria Converti, Daniele Crocetti, Paolo Sapienza, Nadia Bulzonetti, Sassun Richard, Daniela Musio, Andrea Mingoli, Vincenzo Tombolini
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Translational Oncology
Subjects:
High-resolution anoscopy
HPV
Anal canal cancer
Radiotherapy
Response
Treatment failure
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523322002492
Description
Summary:Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patients with anal canal malignant lesions. Results: HRA features could be important to assess the effect of CRT and a risk stratification system should be introduced in clinical practice to better allocate therapeutic interventions. Conclusion: To our knowledge this is the first proposal for HRA findings in anal canal cancer after definitive CRT. We believe that a risk score can be useful to estimate the risk of treatment failure (in term of persistence disease and/or recurrence) and its clinical relevance should not to be underestimated.
ISSN:1936-5233

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