High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era
Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patient...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322002492 |
| _version_ | 1798006288756506624 |
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| author | Francesca De Felice Ilaria Clementi Valeria Converti Daniele Crocetti Paolo Sapienza Nadia Bulzonetti Sassun Richard Daniela Musio Andrea Mingoli Vincenzo Tombolini |
| author_facet | Francesca De Felice Ilaria Clementi Valeria Converti Daniele Crocetti Paolo Sapienza Nadia Bulzonetti Sassun Richard Daniela Musio Andrea Mingoli Vincenzo Tombolini |
| author_sort | Francesca De Felice |
| collection | DOAJ |
| description | Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patients with anal canal malignant lesions. Results: HRA features could be important to assess the effect of CRT and a risk stratification system should be introduced in clinical practice to better allocate therapeutic interventions. Conclusion: To our knowledge this is the first proposal for HRA findings in anal canal cancer after definitive CRT. We believe that a risk score can be useful to estimate the risk of treatment failure (in term of persistence disease and/or recurrence) and its clinical relevance should not to be underestimated. |
| first_indexed | 2024-04-11T12:52:22Z |
| format | Article |
| id | doaj.art-ee1dc99d7b42414db158600e838fff10 |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-04-11T12:52:22Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-ee1dc99d7b42414db158600e838fff102022-12-22T04:23:10ZengElsevierTranslational Oncology1936-52332023-01-0127101590High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 eraFrancesca De Felice0Ilaria Clementi1Valeria Converti2Daniele Crocetti3Paolo Sapienza4Nadia Bulzonetti5Sassun Richard6Daniela Musio7Andrea Mingoli8Vincenzo Tombolini9Department of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, Italy; Corresponding author.Department of Surgery “Pietro Valdoni”, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Surgery “Pietro Valdoni”, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Surgery “Pietro Valdoni”, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Surgery “Pietro Valdoni”, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyRadiotherapy Unit, “Vito Fazzi” Hospital, Lecce, ItalyDepartment of Surgery “Pietro Valdoni”, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyDepartment of Radiotherapy, Policlinico Umberto I “Sapienza” University of Rome, Viale Regina Elena 326, Rome 00161, ItalyPurpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patients with anal canal malignant lesions. Results: HRA features could be important to assess the effect of CRT and a risk stratification system should be introduced in clinical practice to better allocate therapeutic interventions. Conclusion: To our knowledge this is the first proposal for HRA findings in anal canal cancer after definitive CRT. We believe that a risk score can be useful to estimate the risk of treatment failure (in term of persistence disease and/or recurrence) and its clinical relevance should not to be underestimated.http://www.sciencedirect.com/science/article/pii/S1936523322002492High-resolution anoscopyHPVAnal canal cancerRadiotherapyResponseTreatment failure |
| spellingShingle | Francesca De Felice Ilaria Clementi Valeria Converti Daniele Crocetti Paolo Sapienza Nadia Bulzonetti Sassun Richard Daniela Musio Andrea Mingoli Vincenzo Tombolini High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era Translational Oncology High-resolution anoscopy HPV Anal canal cancer Radiotherapy Response Treatment failure |
| title | High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| title_full | High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| title_fullStr | High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| title_full_unstemmed | High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| title_short | High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era |
| title_sort | high resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in covid19 era |
| topic | High-resolution anoscopy HPV Anal canal cancer Radiotherapy Response Treatment failure |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322002492 |
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